Rodríguez-Quiroga A, Buiza C, Mon M A Álvarez de, Quintero J
Servicio de Psiquiatría y Salud Mental, Hospital Universitario Infanta Leonor, Madrid, España.
Departamento de Medicina Legal, Psiquiatría y Patología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, España.
Medicine (Madr). 2020 Dec;13(23):1285-1296. doi: 10.1016/j.med.2020.12.010. Epub 2020 Dec 24.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the coronavirus 2019 (COVID-19) disease, which has caused a pandemic in 2020. This healthcare crisis has had a significant repercussion on the mental health of people who have had the disease itself, those who have undergone restrictive lockdowns, and healthcare professionals who have been working directly or indirectly in patient care. Although the pathological mechanisms related to neuropsychiatric manifestations in patients with COVID-19 are currently unknown, different methods of action through which the central nervous system could be affected have been proposed, including direct or indirect methods. Among them, inflammatory activation through what is known as a "cytokine storm," which is present in both COVID-19 and some mental disorders, seems to play a fundamental role. We also analyze the effects the pandemic has had on the general population, which has had to be remain in lockdown, as well as on healthcare professionals who have been working.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是2019冠状病毒病（COVID-19）的病原体，该病在2020年引发了全球大流行。这场医疗危机对感染该疾病的患者、经历严格封锁措施的人群以及直接或间接参与患者护理工作的医护人员的心理健康产生了重大影响。尽管目前尚不清楚COVID-19患者神经精神症状相关的病理机制，但已提出了中枢神经系统可能受到影响的不同作用方式，包括直接或间接方式。其中，通过所谓的“细胞因子风暴”引发的炎症激活似乎起着关键作用，“细胞因子风暴”在COVID-19和一些精神障碍中均存在。我们还分析了这场大流行对不得不处于封锁状态的普通人群以及一直在工作的医护人员所产生的影响。
