Nguyen Kate, Bui Dinh, Hashemi Mahak, Hocking Dianna M, Mendis Priyan, Strugnell Richard A, Dharmage Shyamali C
School of Engineering, RMIT University, Melbourne, Victoria, Australia.
Centre of Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia.
Risk Manag Healthc Policy. 2021 Jan 22;14:247-252. doi: 10.2147/RMHP.S284897. eCollection 2021.
This work is part of a project on the development of a smart prefabricated sanitising chamber (SPSC) to provide extra measures against the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Stabilised hypochlorous acid (HOCl) is an approved disinfectant against SARS-CoV-2 by the Environmental Protection Association US in its liquid form on non-porous surfaces. This review is extended to cover its viricidal/bactericidal efficacy in aerosolised or sprayed form which showed an effective dose of as low as 20 ppm and the exposure duration of at least 60 s. The aerosolised application was also recommended with particle size of less than 200 μm to increase the contact with pathogens. The review also includes the safety and toxicity of HOCl with different concentrations. The review calls for more investigations into the effect of HOCl in mist and fog form on the respiratory system when transitioning through the proposed SPSC.
这项工作是一个关于开发智能预制消毒舱（SPSC）项目的一部分，该消毒舱旨在提供额外措施以防范严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的传播。稳定态次氯酸（HOCl）在美国环境保护协会的批准下，以液体形式用于无孔表面时可作为对抗SARS-CoV-2的消毒剂。本综述扩展至涵盖其雾化或喷雾形式的杀病毒/杀菌功效，其有效剂量低至20 ppm，暴露持续时间至少为60秒。雾化应用还建议使用小于200μm的粒径，以增加与病原体的接触。该综述还包括不同浓度HOCl的安全性和毒性。该综述呼吁对HOCl以雾状形式通过拟议的SPSC时对呼吸系统的影响进行更多研究。
