新型冠状病毒感染致神经系统疾病的研究进展及其感染机制

Wang Lintao, Ren Zhiguang, Ma Li, Han Yanjie, Wei Wenqiang, Jiang Enshe, Ji Xin-Ying

School of Clinical Medicine, Henan University, Kaifeng, China.

Henan International Joint Laboratory for Nuclear Protein Regulation and Kaifeng Key Laboratory of Infectious Diseases and Bio-safety, Henan University, Kaifeng, China.

Front Neurol. 2021 Jan 13;11:592888. doi: 10.3389/fneur.2020.592888. eCollection 2020.

COVID-19 has spread rapidly worldwide since its outbreak and has now become a major public health problem. More and more evidence indicates that SARS-CoV-2 may not only affect the respiratory system but also cause great harm to the central nervous system. Therefore, it is extremely important to explore in-depth the impact of SARS-CoV-2 infection on the nervous system. In this paper, the possible mechanisms of SARS-CoV-2 invading the central nervous system during COVID-19, and the neurological complications caused by SARS-CoV-2 infection were reviewed.

自COVID-19爆发以来，它已在全球迅速传播，现已成为一个重大的公共卫生问题。越来越多的证据表明，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）不仅可能影响呼吸系统，还会对中枢神经系统造成极大损害。因此，深入探究SARS-CoV-2感染对神经系统的影响极为重要。本文综述了COVID-19期间SARS-CoV-2侵入中枢神经系统的可能机制，以及SARS-CoV-2感染引起的神经并发症。