Ali Yasmin O, Ahmed Khalid, Eckmann Jason, Malli Ahmad
Department of Internal Medicine, Hennepin Healthcare, Minneapolis, Minnesota.
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Gastro Hep Adv. 2025 Apr 24;4(7):100678. doi: 10.1016/j.gastha.2025.100678. eCollection 2025.
Anaplastic multiple myeloma (AMM) is a rare, aggressive variant of multiple myeloma; liver involvement is even more exceedingly rare, with known poor response to conventional treatment. Diagnosis is challenging given the aggressive nature of the disease, with the majority of patients diagnosed postmortem. We present a 66-year-old female who presented with abnormal liver function tests and rapid progression to acute liver failure, with biopsy-proven AMM. To our knowledge, this is the second reported case of AMM of the liver.
间变性多发性骨髓瘤（AMM）是一种罕见的、侵袭性的多发性骨髓瘤变体；肝脏受累更为罕见，已知对传统治疗反应不佳。鉴于该疾病的侵袭性，诊断具有挑战性，大多数患者在死后才被诊断出来。我们报告了一名66岁女性，她出现肝功能检查异常并迅速进展为急性肝衰竭，活检证实为AMM。据我们所知，这是第二例报告的肝脏AMM病例。
