Song Ning, Zhang Wenlong, Ding Yue, Wu Dianjun, Dai Zonghao, Xu Li, Cao Yongguo
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Nanchang Police Dog Base of the Ministry of Public Security, Nanchang, China.
Front Vet Sci. 2021 Jan 14;7:607115. doi: 10.3389/fvets.2020.607115. eCollection 2020.
Leptospirosis is a global zoonotic disease caused by pathogenic , and those infected animals will show a variety of clinical symptoms and even death. The discovery of endemic strains is crucial to produce effective vaccines. In this study, we report that a strain of , isolated from a dog, is pathogenic. Using MLST analysis, the serovar of isolated was identified and found it belongs to Serovar Australis. Then, the virulence of this strain was researched by using hamsters. After infection, all the hamsters died within 4-5 days. Typical pathological changes were found in the liver, kidney, and lung of hamsters. These results all indicated that the isolated was pathogenic. Thus, this study facilitates to identifying local strains and develop a more targeted canine vaccine.
钩端螺旋体病是一种由致病性[病原体名称未给出]引起的全球性人畜共患病，那些被感染的动物会表现出各种临床症状甚至死亡。发现地方流行菌株对于生产有效的疫苗至关重要。在本研究中，我们报告从一只狗身上分离出的一株[菌株名称未给出]具有致病性。通过多位点序列分型（MLST）分析，鉴定了分离出的[菌株名称未给出]的血清型，发现它属于澳洲血清型。然后，利用仓鼠研究了该菌株的毒力。感染后，所有仓鼠在4 - 5天内死亡。在仓鼠的肝脏、肾脏和肺中发现了典型的病理变化。这些结果均表明分离出的[菌株名称未给出]具有致病性。因此，本研究有助于鉴定本地[菌株名称未给出]菌株并开发更具针对性的犬用[钩端螺旋体病疫苗名称未给出]疫苗。
