State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
J Agric Food Chem. 2021 Feb 10;69(5):1441-1454. doi: 10.1021/acs.jafc.0c08085. Epub 2021 Feb 1.
Luteolin, a flavone subclass of flavonoids, is commonly found in food plants and has multiple biological activities. Recently, evidence is growing with regard to the potential of luteolin intake to beneficially affect glycolipid metabolism disorders (GLMDs), particularly insulin resistance, diabetes, and obesity. The aim of this contribution is to provide an overview of recent advances in identifying and understanding the pharmacokinetic properties (absorption, metabolism, and bioavailability) of luteolin, its regulatory effects on glycolipid metabolism, and the underlying mechanisms of action of luteolin in the brain, liver, adipose tissues, and other tissues/organs. Collectively, luteolin or its principal metabolites may contribute to counteracting GLMDs, especially for human obesity and diabetes.
木樨草素是类黄酮的一种黄酮类化合物亚类，在食物植物中很常见，具有多种生物活性。最近，越来越多的证据表明，木樨草素的摄入可能对有益地影响糖脂代谢紊乱（GLMDs），特别是胰岛素抵抗、糖尿病和肥胖症。本综述的目的是提供对木樨草素的药代动力学特性（吸收、代谢和生物利用度）、对糖脂代谢的调节作用以及木樨草素在大脑、肝脏、脂肪组织和其他组织/器官中的作用机制的最新研究进展的概述。总的来说，木樨草素或其主要代谢物可能有助于对抗 GLMDs，特别是对人类肥胖和糖尿病。
