Bayley Hagan, Cazimoglu Idil, Hoskin Charlotte E G
Department of Chemistry, University of Oxford, Oxford, U.K.
Emerg Top Life Sci. 2019 Nov 11;3(5):615-622. doi: 10.1042/ETLS20190120.
While significant advances have been achieved with non-living synthetic cells built from the bottom-up, less progress has been made with the fabrication of synthetic tissues built from such cells. Synthetic tissues comprise patterned three-dimensional (3D) collections of communicating compartments. They can include both biological and synthetic parts and may incorporate features that do more than merely mimic nature. 3D-printed materials based on droplet-interface bilayers are the basis of the most advanced synthetic tissues and are being developed for several applications, including the controlled release of therapeutic agents and the repair of damaged organs. Current goals include the ability to manipulate synthetic tissues by remote signaling and the formation of hybrid structures with fabricated or natural living tissues.
虽然由下而上构建的非生命合成细胞已取得重大进展，但由这类细胞构建合成组织的进展却较小。合成组织由相互连通的隔室组成的有图案的三维（3D）集合体。它们可以包括生物和合成部分，并且可能具有不仅仅是模仿自然的特征。基于液滴界面双层的3D打印材料是最先进合成组织的基础，并且正在被开发用于多种应用，包括治疗剂的控释和受损器官的修复。当前的目标包括通过远程信号操纵合成组织的能力以及与人工制造或天然活组织形成混合结构的能力。
