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LISA与INSURE技术在早产儿新生儿发病率和死亡率方面的比较。

The Comparison of LISA and INSURE techniques in term of neonatal morbidities and mortality among premature infants.

作者信息

Silahli Musa, Tekin Mehmet

机构信息

Neonatal Intensive Care Unit, Baskent University Konya Training and Research Hospital, Konya, Turkey..

Department of Pediatrics, Baskent University Konya Training and Research Hospital, Konya, Turkey..

出版信息

Acta Biomed. 2020 Nov 10;91(4):e2020189. doi: 10.23750/abm.v91i4.8845.

DOI:10.23750/abm.v91i4.8845
PMID:33525282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7927556/
Abstract

BACKGROUND AND AIM OF THE WORK

Respiratory distress syndrome (RDS) is the most common cause of respiratory failure among premature infants. The most important choice for the treatment of  RDS is still exogenous surfactant replacement therapy and respiratory support. Today, there are some different surfactant applying techniques. In this study, we aimed to evaluate the effects of the surfactant administration techniques in premature infants less than 33 weeks of gestational age.

METHODS

The medical data were collected retrospectively from the medical records of Baskent University, Konya Training and Research Hospital between 2010 and 2016.  The patient divided into two subgroups as Less Invasive Surfactant Administration (LISA) group (n: 35) and Intubation- Surfactant administration and rapid Extubation (INSURE) group (n: 30). Two surfactant administration techniques were evaluated on the neonatal morbidities and mortality among premature infants.

RESULTS

There were no significant differences in maternal and neonatal characteristics between the two groups. Duration on the nasal continues positive airway pressure (nCPAP) is significantly higher in the LISA group as compared with the INSURE group (p<0.001).  And also between two groups, there were no significant differences in term of neonatal mortality and morbidities.

CONCLUSION

The technique of the surfactant administration has no effect on the postnatal morbidities. LISA method is safe and effective as much as INSURE method, which is still a good alternative in centers with lack of experience about LISA. We need to perform studies that have larger sample size and prospective randomized controlled trials.

摘要

工作背景与目的

呼吸窘迫综合征（RDS）是早产儿呼吸衰竭最常见的原因。治疗RDS最重要的选择仍然是外源性表面活性物质替代疗法和呼吸支持。如今，有一些不同的表面活性物质应用技术。在本研究中，我们旨在评估表面活性物质给药技术对孕周小于33周的早产儿的影响。

方法

回顾性收集2010年至2016年期间巴斯肯大学科尼亚培训与研究医院的病历中的医学数据。将患者分为两个亚组，即微创表面活性物质给药（LISA）组（n = 35）和插管 - 表面活性物质给药及快速拔管（INSURE）组（n = 30）。评估两种表面活性物质给药技术对早产儿新生儿发病率和死亡率的影响。

结果

两组之间的母体和新生儿特征无显著差异。LISA组的经鼻持续气道正压通气（nCPAP）持续时间显著高于INSURE组（p<0.001）。而且两组之间在新生儿死亡率和发病率方面无显著差异。

结论

表面活性物质给药技术对出生后的发病率没有影响。LISA方法与INSURE方法一样安全有效，在缺乏LISA经验的中心，LISA方法仍是一个很好的选择。我们需要进行样本量更大的研究和前瞻性随机对照试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0b/7927556/4885c27245a9/ACTA-91-189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0b/7927556/4885c27245a9/ACTA-91-189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0b/7927556/4885c27245a9/ACTA-91-189-g001.jpg

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