Lippi Giuseppe, Sanchis-Gomar Fabian
Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma..
Department of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain.
Acta Biomed. 2020 Nov 10;91(4):e2020104. doi: 10.23750/abm.v91i4.8460.
The assessment of hematological profile requires to identify possible sources of biological variability, including exercise-related variations. This study was hence aimed to evaluate hematological profile variations in amateur and professional athletes, and establish their possible dependence on cumulative training volume.
The study population consisted of 59 sedentary male subjects, 78 amateur and 80 professional male cyclists, in whom a large number of hematological variables were measured at rest.
Red blood cell (RBC) count and hemoglobin were decreased in the two athlete cohorts compared to sedentary subjects, but did not differ between amateur and professional cyclists. Hematocrit was gradually and significantly decreased in parallel with cumulative training volume. Amateur cyclists displayed higher mean corpuscular volume (MCV) and lower mean corpuscular hemoglobin concentration (MCHC) values than sedentary subjects and professional cyclists, whilst mean corpuscular hemoglobin (MCH) was higher in professional cyclists. The reticulocyte count and soluble transferrin receptor (sTFR) values were similar across all groups. Serum ferritin was higher in professional cyclists than in the other two groups, whilst transferrin gradually decreased from sedentary group to the two cohorts of amateur and professional cyclists. In univariate analysis, cumulative training volume was inversely associated with age, body mass index (BMI), RBC count, hematocrit, hemoglobin and transferrin, whilst a positive association was found with ferritin. In multivariate analysis, BMI, RBC count and ferritin remained significantly associated with training volume.
These results show that the volume of endurance training may affect some hematological variables.
血液学指标评估需要识别生物变异性的可能来源，包括与运动相关的变化。因此，本研究旨在评估业余和职业运动员的血液学指标变化，并确定其可能与累积训练量的相关性。
研究人群包括59名久坐不动的男性受试者、78名业余男性自行车运动员和80名职业男性自行车运动员，在静息状态下测量了大量血液学变量。
与久坐不动的受试者相比，两个运动员队列中的红细胞（RBC）计数和血红蛋白降低，但业余和职业自行车运动员之间无差异。血细胞比容与累积训练量平行逐渐且显著降低。业余自行车运动员的平均红细胞体积（MCV）高于久坐不动的受试者和职业自行车运动员，平均红细胞血红蛋白浓度（MCHC）低于他们，而职业自行车运动员的平均红细胞血红蛋白（MCH）更高。所有组的网织红细胞计数和可溶性转铁蛋白受体（sTFR）值相似。职业自行车运动员的血清铁蛋白高于其他两组，而转铁蛋白从久坐不动组到业余和职业自行车运动员两组逐渐降低。单因素分析中，累积训练量与年龄、体重指数（BMI）、RBC计数、血细胞比容、血红蛋白和转铁蛋白呈负相关，而与铁蛋白呈正相关。多因素分析中，BMI、RBC计数和铁蛋白仍与训练量显著相关。
这些结果表明耐力训练量可能会影响一些血液学变量。
