Lengelé Laetitia, Bruyère Olivier, Beaudart Charlotte, Reginster Jean-Yves, Locquet Médéa
WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, CHU-Sart Tilman, Quartier Hôpital, Avenue Hippocrate 13 (Bât. B23), 4000 Liège, Belgium.
Department of Sport Rehabilitation Sciences, University of Liège, 4000 Liège, Belgium.
Nutrients. 2021 Jan 28;13(2):407. doi: 10.3390/nu13020407.
This study aimed to assess the impact of malnutrition on the 5-year evolution of physical performance, muscle mass and muscle strength in participants from the SarcoPhAge cohort, consisting of community-dwelling older adults. The malnutrition status was assessed at baseline (T0) according to the "Global Leadership Initiatives on Malnutrition" (GLIM) criteria, and the muscle parameters were evaluated both at T0 and after five years of follow-up (T5). Lean mass, muscle strength and physical performance were assessed using dual X-ray absorptiometry, handgrip dynamometry, the short physical performance battery test and the timed up and go test, respectively. Differences in muscle outcomes according to nutritional status were tested using Student's -test. The association between malnutrition and the relative 5-year change in the muscle parameters was tested using multiple linear regressions adjusted for several covariates. A total of 411 participants (mean age of 72.3 ± 6.1 years, 56% women) were included. Of them, 96 individuals (23%) were diagnosed with malnutrition at baseline. Their muscle parameters were significantly lower than those of the well-nourished patients both at baseline and after five years of follow-up (all -values < 0.05), except for muscle strength in women at T5, which was not significantly lower in the presence of malnutrition. However, the 5-year changes in muscle parameters of malnourished individuals were not significantly different than those of well-nourished individuals (all -values > 0.05).
本研究旨在评估营养不良对SarcoPhAge队列参与者身体机能、肌肉质量和肌肉力量5年演变的影响，该队列由社区居住的老年人组成。根据“全球营养不良领导倡议”（GLIM）标准在基线（T0）评估营养不良状况，并在T0和随访5年后（T5）评估肌肉参数。分别使用双能X线吸收法、握力测量法、简短身体机能测试电池和定时起立行走测试评估瘦体重、肌肉力量和身体机能。根据营养状况测试肌肉结果的差异，采用学生t检验。使用针对多个协变量进行调整的多元线性回归测试营养不良与肌肉参数5年相对变化之间的关联。共纳入411名参与者（平均年龄72.3±6.1岁，56%为女性）。其中，96人（23%）在基线时被诊断为营养不良。他们的肌肉参数在基线和随访5年后均显著低于营养良好的患者（所有P值<0.05），但T5时女性的肌肉力量除外，在存在营养不良的情况下，其肌肉力量没有显著降低。然而，营养不良个体的肌肉参数5年变化与营养良好个体的变化没有显著差异（所有P值>0.05）。
