McCully K K, Argov Z, Boden B P, Brown R L, Bank W J, Chance B
Department of Biochem/Biophysics, University of Pennsylvania, Philadelphia 19104.
Muscle Nerve. 1988 Mar;11(3):212-6. doi: 10.1002/mus.880110304.
Strenuous exercise can result in muscle injury that may persist for 2 weeks. Our purpose was to determine if muscle injury can be detected with 31-P magnetic resonance spectroscopy. Normal subjects performed repeated lengthening contractions with either arms or legs designed to result in mild muscle injury. One hour after the arm exercise, there was a significant increase in the inorganic phosphate to phosphocreatine ratio (Pi/PCr), with the maximum increase in Pi/PCr occurring 1 day postexercise (0.12 +/- 0.01 to 0.21 +/- 0.05). Pi/PCr remained elevated for 3-10 days. Similar results were seen following the leg exercise protocol. ATP/(Pi + PCr) decreased in all the arm exercised subjects. Exercise protocols that did not contain lengthening contractions did not result in changes of Pi/PCr or ATP/(Pi + PCr). Patients with various neuromuscular diseases with evidence of muscle damage (elevated CK, muscle soreness, and histopathological findings) also showed increased Pi/PCr at rest. We conclude that elevated Pi/PCr at rest can reflect nonspecific muscle damage in normal and diseased subjects.
剧烈运动可导致肌肉损伤，这种损伤可能持续两周。我们的目的是确定能否用31-P磁共振波谱检测到肌肉损伤。正常受试者用手臂或腿部进行重复的拉长收缩，旨在造成轻度肌肉损伤。手臂运动1小时后，无机磷酸与磷酸肌酸的比率（Pi/PCr）显著增加，Pi/PCr在运动后1天达到最大增加（从0.12±0.01增至0.21±0.05）。Pi/PCr持续升高3至10天。腿部运动方案后也出现了类似结果。所有进行手臂运动的受试者中，ATP/（Pi + PCr）均降低。不包含拉长收缩的运动方案未导致Pi/PCr或ATP/（Pi + PCr）发生变化。有肌肉损伤证据（肌酸激酶升高、肌肉酸痛和组织病理学发现）的各种神经肌肉疾病患者在静息状态下也显示Pi/PCr升高。我们得出结论，静息状态下Pi/PCr升高可反映正常和患病受试者的非特异性肌肉损伤。
