Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Nurs Open. 2021 May;8(3):1424-1435. doi: 10.1002/nop2.759. Epub 2021 Feb 2.
To evaluate whether high-intensity interval training (HIIT) was superior to low-intensity training or usual care among patients after percutaneous coronary intervention. The hypothesis was that HIIT would help patients after percutaneous coronary intervention (PCI) improve cardiopulmonary function, lipid profiles and in-stent restenosis.
A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA)2009 Checklist.
Randomized controlled trials (RCTs) focusing on HIIT programme in patients after PCI were searched in Cochrane Library, Web of Science Core Collection, EMbase, PubMed, China National Knowledge Infrastructure (CNKI) and SinoMed from the inception to 24 March 2020. Standard Mean difference (SMD) and 95% confidence intervals (CI) were performed to summarize the effect sizes.
Six RCTs (247 patients) met the criteria. HIIT programme had a statistically significant effect on raising left ventricular ejection function (LVEF) (SMD = 0.38, 95%CI [0.03, 0.73], I = 3%), VO (SMD = 0.94, 95%CI [0.61, 1.28], I = 0%), as well as improving the serum level of high-density lipoprotein (SMD = 0.55, 95%CI [0.06, 1.03], I = 0%) and late luminal loss (SMD = -0.65, 95%CI [-1.07, -0.23], I = 0%). But HIIT had no prominent effect on improving heart rate (SMD = -0.04, 95%CI [-0.29, 0.21], I = 0%). Summarily, HIIT programme appears to be favourable for CAD patients after PCI by improving cardiopulmonary function, such as LVEF and VO , as well as reducing late luminal loss in per stented arteries. Nevertheless, HIIT has no advantage for adjusting heart rate. More researches with rigorous methods are warranted to explore the controversy about lipid profiles.
评估高强度间歇训练（HIIT）是否优于经皮冠状动脉介入治疗（PCI）后的低强度训练或常规护理。假设是 HIIT 将帮助 PCI 后的患者改善心肺功能、血脂谱和支架内再狭窄。
根据系统评价和荟萃分析的首选报告项目（PRISMA）2009 清单进行系统评价和荟萃分析。
检索 Cochrane 图书馆、Web of Science 核心合集、EMbase、PubMed、中国知网（CNKI）和 SinoMed 从成立到 2020 年 3 月 24 日的 PCI 后 HIIT 计划的随机对照试验（RCT）。使用标准均数差（SMD）和 95%置信区间（CI）汇总效应大小。
六项 RCT（247 名患者）符合标准。HIIT 方案在提高左心室射血功能（LVEF）（SMD=0.38，95%CI [0.03，0.73]，I²=3%）、VO（SMD=0.94，95%CI [0.61，1.28]，I²=0%）方面具有统计学意义，以及改善高密度脂蛋白（SMD=0.55，95%CI [0.06，1.03]，I²=0%）和晚期管腔丢失（SMD=-0.65，95%CI [-1.07，-0.23]，I²=0%）的血清水平方面有显著效果。但是 HIIT 对改善心率（SMD=-0.04，95%CI [-0.29，0.21]，I²=0%）没有明显作用。总之，HIIT 方案似乎通过改善心肺功能，如 LVEF 和 VO，以及减少支架内动脉的晚期管腔丢失，对 CAD 患者 PCI 后有益。然而，HIIT 对调整心率没有优势。需要更多方法严谨的研究来探讨血脂谱的争议。
