• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

印度 SARS-CoV-2 的临床和全基因组特征。

Clinical and whole genome characterization of SARS-CoV-2 in India.

机构信息

Virus Research Laboratory, Department of Zoology, Osmania University, Hyderabad, India.

Department of Microbiology, Gandhi Medical College and Hospital, Secunderabad, India.

出版信息

PLoS One. 2021 Feb 2;16(2):e0246173. doi: 10.1371/journal.pone.0246173. eCollection 2021.

DOI:10.1371/journal.pone.0246173
PMID:33529260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7853523/
Abstract

We report clinical profile of hundred and nine patients with SARS CoV-2 infection, and whole genome sequences (WGS) of seven virus isolates from the first reported cases in India, with various international travel histories. Comorbidities such as diabetes, hypertension, and cardiovascular disease were frequently associated with severity of the disease. WBC and neutrophil counts showed an increase, while lymphocyte counts decreased in patients with severe infection suggesting a possible neutrophil mediated organ damage, while immune activity may be diminished with decrease in lymphocytes leading to disease severity. Increase in SGOT, SGPT and blood urea suggests the functional deficiencies of liver, heart, and kidney in patients who succumbed to the disease when compared to the group of recovered patients. The WGS analysis showed that these isolates were classified into two clades: I/A3i, and A2a (four according to GISAID: O, L, GR, and GH). Further, WGS phylogeny and travel history together indicate possible transmission from Middle East and Europe. Three S protein variants: Wuhan reference, D614G, and Y28H were identified predicted to possess different binding affinities to host ACE2.

摘要

我们报告了 109 例 SARS-CoV-2 感染患者的临床特征，以及印度首例报告病例的 7 个病毒分离株的全基因组序列 (WGS)，这些病毒分离株均有不同的国际旅行史。糖尿病、高血压和心血管疾病等合并症常与疾病的严重程度相关。白细胞和中性粒细胞计数增加，而淋巴细胞计数减少，这表明严重感染的患者可能存在中性粒细胞介导的器官损伤，而淋巴细胞减少可能导致免疫活性降低，从而导致疾病加重。与康复组相比，死于该病的患者的 SGOT、SGPT 和血尿素水平升高，表明肝、心和肾功能受损。WGS 分析表明，这些分离株分为两个分支：I/A3i 和 A2a（根据 GISAID 分为 O、L、GR 和 GH）。此外，WGS 系统发育和旅行史共同表明，可能来自中东和欧洲的传播。鉴定出三种 S 蛋白变体：武汉参考株、D614G 和 Y28H，它们可能具有不同的与宿主 ACE2 的结合亲和力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/47e40b96701d/pone.0246173.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/d5ea0ca4991b/pone.0246173.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/01b18ada5756/pone.0246173.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/9945f57b209c/pone.0246173.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/dfc1612b6668/pone.0246173.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/e5cba7f69f16/pone.0246173.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/a1f6e2233fa1/pone.0246173.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/47e40b96701d/pone.0246173.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/d5ea0ca4991b/pone.0246173.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/01b18ada5756/pone.0246173.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/9945f57b209c/pone.0246173.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/dfc1612b6668/pone.0246173.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/e5cba7f69f16/pone.0246173.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/a1f6e2233fa1/pone.0246173.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d369/7853523/47e40b96701d/pone.0246173.g007.jpg

相似文献

1
Clinical and whole genome characterization of SARS-CoV-2 in India.印度 SARS-CoV-2 的临床和全基因组特征。
PLoS One. 2021 Feb 2;16(2):e0246173. doi: 10.1371/journal.pone.0246173. eCollection 2021.
2
Whole-genome sequencing of SARS-CoV-2 reveals the detection of G614 variant in Pakistan.全基因组测序揭示了 SARS-CoV-2 在巴基斯坦的 G614 变异株检测。
PLoS One. 2021 Mar 23;16(3):e0248371. doi: 10.1371/journal.pone.0248371. eCollection 2021.
3
Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.新冠病毒家族聚集性病例中分离的 SARS-CoV-2 的分子流行病学研究。
BMC Med Genomics. 2021 Jun 1;14(1):144. doi: 10.1186/s12920-021-00990-3.
4
Emergence of SARS-CoV-2 omicron variant JN.1 in Tamil Nadu, India - Clinical characteristics and novel mutations.印度泰米尔纳德邦出现 SARS-CoV-2 奥密克戎变异株 JN.1——临床特征和新突变。
Sci Rep. 2024 Jul 30;14(1):17476. doi: 10.1038/s41598-024-68678-z.
5
COVID-19 genome surveillance: A geographical landscape and mutational mapping of SARS-CoV-2 variants in central India over two years.2019冠状病毒病基因组监测：印度中部两年间严重急性呼吸综合征冠状病毒2变体的地理分布及突变图谱
Virus Res. 2024 Jun;344:199365. doi: 10.1016/j.virusres.2024.199365. Epub 2024 Mar 29.
6
Emergence and expansion of highly infectious spike protein D614G mutant SARS-CoV-2 in central India.高传染性刺突蛋白D614G突变型严重急性呼吸综合征冠状病毒2在印度中部的出现与传播。
Sci Rep. 2021 Sep 13;11(1):18126. doi: 10.1038/s41598-021-95822-w.
7
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics.常见突变对 SARS-CoV-2 刺突 RBD 及其配体人 ACE2 受体结合亲和力和动力学的影响。
Elife. 2021 Aug 26;10:e70658. doi: 10.7554/eLife.70658.
8
SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia.在费城住院患者中 SARS-CoV-2 的时空基因组变异。
mBio. 2021 Jan 19;12(1):e03456-20. doi: 10.1128/mBio.03456-20.
9
Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure.土耳其 SARS-CoV-2 基因组的突变特征及其对刺突蛋白结构的影响。
PLoS One. 2021 Dec 6;16(12):e0260438. doi: 10.1371/journal.pone.0260438. eCollection 2021.
10
The expression of hACE2 receptor protein and its involvement in SARS-CoV-2 entry, pathogenesis, and its application as potential therapeutic target.hACE2 受体蛋白的表达及其在 SARS-CoV-2 进入、发病机制中的作用及其作为潜在治疗靶点的应用。
Tumour Biol. 2021;43(1):177-196. doi: 10.3233/TUB-200084.

引用本文的文献

1
Genomic epidemiology of SARS-CoV-2 from Uttar Pradesh, India.印度北方邦 SARS-CoV-2 的基因组流行病学研究。
Sci Rep. 2023 Sep 8;13(1):14847. doi: 10.1038/s41598-023-42065-6.
2
Whole-Genome Comparison of Representatives of All Variants of SARS-CoV-2, Including Subvariant BA.2 and the GKA Clade.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）所有变体代表的全基因组比较，包括BA.2亚变体和GKA进化枝。
Adv Virol. 2023 Mar 9;2023:6476626. doi: 10.1155/2023/6476626. eCollection 2023.
3
Multifaceted Assessment of Wastewater-Based Epidemiology for SARS-CoV-2 in Selected Urban Communities in Davao City, Philippines: A Pilot Study.

本文引用的文献

1
A Distinct Phylogenetic Cluster of Indian Severe Acute Respiratory Syndrome Coronavirus 2 Isolates.印度严重急性呼吸综合征冠状病毒2分离株的一个独特系统发育簇。
Open Forum Infect Dis. 2020 Sep 18;7(11):ofaa434. doi: 10.1093/ofid/ofaa434. eCollection 2020 Nov.
2
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.SARS-CoV-2 反向遗传学揭示了呼吸道感染的可变梯度。
Cell. 2020 Jul 23;182(2):429-446.e14. doi: 10.1016/j.cell.2020.05.042. Epub 2020 May 27.
3
Targeting potential drivers of COVID-19: Neutrophil extracellular traps.
多方面评估菲律宾达沃市选定城区基于污水的 SARS-CoV-2 流行病学：一项试点研究。
Int J Environ Res Public Health. 2022 Jul 19;19(14):8789. doi: 10.3390/ijerph19148789.
4
Proficiency testing for SARS-CoV-2 whole genome sequencing.SARS-CoV-2 全基因组测序能力验证。
Pathology. 2022 Aug;54(5):615-622. doi: 10.1016/j.pathol.2022.04.002. Epub 2022 Jun 29.
5
Molecular Analysis of SARS-CoV-2 Lineages in Armenia.亚美尼亚的 SARS-CoV-2 谱系的分子分析。
Viruses. 2022 May 17;14(5):1074. doi: 10.3390/v14051074.
6
Genome Sequencing Reveals a Mixed Picture of SARS-CoV-2 Variant of Concern Circulation in Eastern Uttar Pradesh, India.基因组测序揭示了印度北方邦东部令人担忧的新冠病毒变异株传播的复杂情况。
Front Med (Lausanne). 2022 Jan 7;8:781287. doi: 10.3389/fmed.2021.781287. eCollection 2021.
7
Genomic Surveillance and Phylodynamic Analyses Reveal the Emergence of Novel Mutations and Co-mutation Patterns Within SARS-CoV-2 Variants Prevalent in India.基因组监测和系统动力学分析揭示了印度流行的新冠病毒变异株中新型突变和共突变模式的出现。
Front Microbiol. 2021 Jul 29;12:703933. doi: 10.3389/fmicb.2021.703933. eCollection 2021.
靶向 COVID-19 的潜在驱动因素：中性粒细胞胞外陷阱。
J Exp Med. 2020 Jun 1;217(6). doi: 10.1084/jem.20200652.
4
Full-genome sequences of the first two SARS-CoV-2 viruses from India.印度最早发现的两种 SARS-CoV-2 病毒的全基因组序列。
Indian J Med Res. 2020;151(2 & 3):200-209. doi: 10.4103/ijmr.IJMR_663_20.
5
Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study.85 例武汉 COVID-19 死亡病例的临床特征。一项回顾性观察研究。
Am J Respir Crit Care Med. 2020 Jun 1;201(11):1372-1379. doi: 10.1164/rccm.202003-0543OC.
6
Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia.新型冠状病毒肺炎外周血淋巴细胞亚群特征变化。
J Infect Dis. 2020 May 11;221(11):1762-1769. doi: 10.1093/infdis/jiaa150.
7
Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality.2019冠状病毒病（COVID-19）与心肌损伤及死亡率的关联
JAMA Cardiol. 2020 Jul 1;5(7):751-753. doi: 10.1001/jamacardio.2020.1105.
8
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.113 例新冠肺炎死亡患者的临床特征：回顾性研究。
BMJ. 2020 Mar 26;368:m1091. doi: 10.1136/bmj.m1091.
9
Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study.中国武汉 2019 年冠状病毒病死亡和康复病例的临床特征：回顾性研究。
Chin Med J (Engl). 2020 Jun 5;133(11):1261-1267. doi: 10.1097/CM9.0000000000000824.
10
A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2.一种序列同源性和生物信息学方法可预测针对 SARS-CoV-2 的免疫反应的候选靶点。
Cell Host Microbe. 2020 Apr 8;27(4):671-680.e2. doi: 10.1016/j.chom.2020.03.002. Epub 2020 Mar 16.