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Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.类 Meteorin 通过 Stat3/IGF-1 机制促进骨骼肌修复。
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Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.呼吸表型学在心脏线粒体中多种蛋白质超酰化模型中的研究揭示了对生物能量学的微小影响。
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The AMPK/p27 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.AMPK/p27 轴调控衰老骨骼肌干细胞的自噬/凋亡决定。
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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.BCKDH 激酶和磷酸酶通过调节 ATP-柠檬酸裂解酶整合支链氨基酸和脂质代谢。
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The KSEA App: a web-based tool for kinase activity inference from quantitative phosphoproteomics.KSEA应用程序：一种基于网络的工具，用于从定量磷酸化蛋白质组学推断激酶活性。
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The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition.蛋白质组交换联盟2017年：支持蛋白质组学公共数据存缴方面的文化变革。
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慢性热量限制维持老年骨骼肌中的年轻磷酸化蛋白质组。

Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.

机构信息

Duke Molecular Physiology Institute, Duke University Medical School, Durham, NC, USA.

Duke Molecular Physiology Institute, Duke University Medical School, Durham, NC, USA; Adams School of Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.

出版信息

Mech Ageing Dev. 2021 Apr;195:111443. doi: 10.1016/j.mad.2021.111443. Epub 2021 Jan 30.

DOI:10.1016/j.mad.2021.111443
PMID:33529682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8035222/
Abstract

Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing several known "pro-aging" pathways including Protein kinase A (PKA). This study validates global signaling changes in skeletal muscle during CR.

摘要

热量限制（CR）可以延长衰老骨骼肌的功能，但分子机制尚不完全清楚。我们对自由进食的年轻和老年小鼠以及限制热量进食的老年小鼠的肌肉进行了磷酸化蛋白质组分析。CR 促进了一种年轻的磷酸化蛋白质组特征，抑制了几种已知的“促衰老”途径，包括蛋白激酶 A（PKA）。这项研究验证了 CR 期间骨骼肌中的全局信号变化。