Zheng QiongFei, Ying Qinli, Ren ZhengJu, Zhang Qin, Lu DongLiang, Wang HongBai, Wei WuRan
Department of Rehabilitation, Qianjiang Central Hospital of, Chongqing, Qianjiang.
Department of Urology, The Second Affiliated Hospital, Chongqing Medical University.
Medicine (Baltimore). 2021 Jan 29;100(4):e23816. doi: 10.1097/MD.0000000000023816.
The evidence for associations between family history of prostate cancer and the risk of breast cancer and ovarian cancer is inconclusive. The first systematic review and meta-analysis of studies was conducted to assess the risk of breast cancer and ovarian cancer associated with a family history of prostate cancer.A literature search was conducted using MEDLINE, Embase and Web of science databases up to January 31, 2019. Data were screened and extracted independently by 2 reviewers. The pooled risk ratio (RR) and its 95% confidence interval (CI) were calculated using random-effects models. The GRADE approach was used to assess the quality of evidence.Nine observational studies including 8,011,625 individuals were included in the meta-analysis. The meta-analysis showed that family history of prostate cancer in first-degree relatives was associated with an increased risk of breast cancer (RR 1.12, 95%CI 1.09 to 1.14) with moderate quality evidence, subgroup analysis showed consistent results. Compared with no family history of prostate cancer, history of prostate cancer in first-degree relatives was associated with a slight risk of ovarian cancer (1.10, 95%CI 1.01 to 1.20) with moderate quality evidence. Family history of prostate cancer among sibling was associated with a 17% increased risk of ovarian cancer (95% CI 1.03 to 1.34), however, no significant association was found between family history of prostate cancer among parent and risk of ovarian cancer (RR 1.19, 95% CI 0.84 to 1.70).This review demonstrates that women with a family history of prostate cancer in first-degree relatives was associated with an increased risk of breast cancer and ovarian cancer. These findings may aid in screening, earlier detection and treatment of women with a family history of prostate cancer in first-degree relatives.
前列腺癌家族史与乳腺癌和卵巢癌风险之间的关联证据尚无定论。开展了第一项关于相关研究的系统评价和荟萃分析，以评估与前列腺癌家族史相关的乳腺癌和卵巢癌风险。利用MEDLINE、Embase和科学网数据库进行了截至2019年1月31日的文献检索。由2名审阅者独立筛选和提取数据。采用随机效应模型计算合并风险比（RR）及其95%置信区间（CI）。采用GRADE方法评估证据质量。荟萃分析纳入了9项观察性研究，共8,011,625人。荟萃分析显示，一级亲属中有前列腺癌家族史与乳腺癌风险增加相关（RR 1.12，95%CI 1.09至1.14），证据质量中等，亚组分析结果一致。与无前列腺癌家族史相比，一级亲属中有前列腺癌病史与卵巢癌风险略有增加相关（1.10，95%CI 1.01至1.20），证据质量中等。兄弟姐妹中有前列腺癌家族史与卵巢癌风险增加17%相关（95%CI 1.03至1.34），然而，父母中有前列腺癌家族史与卵巢癌风险之间未发现显著关联（RR 1.19，95%CI 0.84至1.70）。本综述表明，一级亲属中有前列腺癌家族史的女性与乳腺癌和卵巢癌风险增加相关。这些发现可能有助于对一级亲属中有前列腺癌家族史的女性进行筛查、早期检测和治疗。
