Alsubhi Hassan, Gabbani Mohammad, Alsolami Abdulsalam, Alosaimi Mohammed, Abuljadayel Jameel, Taju Waleed, Bukhari Omair
Umm Al Qura University, Faculty of Dentistry, Makkah 21955, Saudi Arabia.
Department of Preventive Dentistry, Umm Al Qura University, Faculty of Dentistry, Makkah 21955, Saudi Arabia.
Int J Dent. 2021 Jan 18;2021:6644069. doi: 10.1155/2021/6644069. eCollection 2021.
Enamel demineralization and white-spot lesions (WSLs) around the orthodontic brackets are common clinical complications after orthodontic fixed appliance therapy. WSLs form mainly due to plaque deposition around the brackets during the orthodontic treatment period. This study was designed to compare and evaluate the efficacy of two different remineralization agents on WSLs, which are "Clinpro 5000 and Colgate Sensitive Pro-Relief". 27 caries-free human premolar teeth were collected after extraction for orthodontic purposes. The crowns were set in acrylic resin, and the entire surfaces were coated with nail varnish apart from an area of 4 × 4 mm on the buccal surface. The surface microhardness (SMH) was measured using the Vickers microhardness testing machine at baseline, after demineralization, and after treatment. Then, the different SMH values were statistically analyzed using mixed-effects linear regression. All samples were immersed in demineralizing solution for ten days to create WSLs, and then the teeth were allocated randomly into one of the three groups: Group 1 (control group-immersed in artificial saliva), Group 2 (treated with Colgate sensitive Pro-Relief toothpaste), and Group 3 (Clinpro 5000 toothpaste). Cycles of treatment were done for 5 minutes every 12 hours for 14 days. The samples were stored in freshly prepared artificial saliva between cycles. The mixed-effects model was used to quantify the effect of different remineralization agents. All statistics were computed using STATA software (version14.1; Stata, College Station, TX). All statistical tests were two-tailed and interpreted at the 0.05 significance level. Both agents improved the surface hardness. Clinpro 5000 improved the surface hardness by 12.7 ( value 0.012), and Colgate Sensitive Pro-Relief improved surface hardness by 18.2 ( value <0.0001), However when both treatments are compared with each other, there was no statistical significance among them. When compared to the control group, both treatments "Clinpro™ 5000 and Colgate Sensitive Pro-Relief" have significantly improved enamel's SMH.
正畸固定矫治器治疗后，正畸托槽周围的牙釉质脱矿和白斑病变（WSLs）是常见的临床并发症。WSLs主要是在正畸治疗期间由于托槽周围的菌斑沉积而形成的。本研究旨在比较和评估两种不同再矿化剂（“Clinpro 5000和高露洁敏感专业舒缓牙膏”）对WSLs的疗效。为正畸目的拔除后收集27颗无龋的人类前磨牙。将牙冠置于丙烯酸树脂中，除颊面4×4mm区域外，整个表面均涂有指甲油。在基线、脱矿后和治疗后，使用维氏显微硬度测试机测量表面显微硬度（SMH）。然后，使用混合效应线性回归对不同的SMH值进行统计分析。将所有样本浸入脱矿溶液中10天以产生WSLs，然后将牙齿随机分配到三组之一：第1组（对照组 - 浸入人工唾液中）、第2组（用高露洁敏感专业舒缓牙膏治疗）和第3组（Clinpro 5000牙膏）。治疗周期为每12小时进行5分钟，共14天。在周期之间，将样本储存在新制备的人工唾液中。使用混合效应模型来量化不同再矿化剂的效果。所有统计均使用STATA软件（版本14.1；Stata，College Station，TX）进行计算。所有统计检验均为双侧检验，并在0.05显著性水平上进行解释。两种试剂均提高了表面硬度。Clinpro 5000使表面硬度提高了12.7（P值0.012），高露洁敏感专业舒缓牙膏使表面硬度提高了18.2（P值<0.0001），然而，当将两种治疗方法相互比较时，它们之间没有统计学意义。与对照组相比，两种治疗方法“Clinpro™ 5000和高露洁敏感专业舒缓牙膏”均显著提高了牙釉质的SMH。
