Gelenkzentrum Rhein-Main, Wiesbaden, Germany.
Lower Extremity Orthopaedics, Musculoskeletal Centre, Schulthess Clinic, Zurich, Switzerland.
Cartilage. 2021 Dec;13(1_suppl):1124S-1136S. doi: 10.1177/1947603520942952. Epub 2020 Jul 25.
Cartilage defects in the knee are being diagnosed with increased frequency and are treated with a variety of techniques. The aim of any cartilage repair procedure is to generate the highest tissue quality, which might correlate with improved clinical outcomes, return-to-sport, and long-term durability. Minced cartilage implantation (MCI) is a relatively simple and cost-effective technique to transplant autologous cartilage fragments in a single-step procedure. Minced cartilage has a strong biologic potential since autologous, activated non-dedifferentiated chondrocytes are utilized. It can be used both for small and large cartilage lesions, as well as for osteochondral lesions. As it is purely an autologous and homologous approach, it lacks a significant regulatory oversight process and can be clinically adopted without such limitations. The aim of this narrative review is to provide an overview of the current evidence supporting autologous minced cartilage implantation.
膝关节软骨缺损的诊断频率正在增加，并且可以采用多种技术进行治疗。任何软骨修复程序的目的都是产生最高质量的组织，这可能与改善临床结果、重返运动和长期耐用性相关。软骨碎块植入术（MCI）是一种相对简单且具有成本效益的技术，可以在单步手术中移植自体软骨碎片。由于使用了自体、激活的未分化软骨细胞，软骨碎块具有很强的生物学潜力。它既可以用于小的和大的软骨损伤，也可以用于骨软骨损伤。由于它纯粹是一种自体同源的方法，因此缺乏重要的监管监督过程，可以在没有这些限制的情况下在临床上采用。本叙述性综述的目的是提供当前支持自体软骨碎块植入术的证据概述。
