Shanghai Fengxian District Central Hospital, No. 6600, Nanfeng Road, 201499 Shanghai, China.
Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200127 Shanghai, China.
J Immunol Res. 2021 Jan 18;2021:6619302. doi: 10.1155/2021/6619302. eCollection 2021.
The occurrence of hepatocellular carcinoma (HCC) is closely related to the chronic inflammation which caused liver fibrosis and cirrhosis, and the interaction between HCC and its microenvironment further drives tumorigenesis. However, the single-cell resolution study is lacking, which limits our molecular understanding of tumour biology in the liver. Here, using published single-cell sequencing technology (scRNA-seq) database, we analyzed the liver microenvironment at high resolution in an unbiased manner and demonstrated the transcriptomic comparison between various cell populations and subpopulations in HCC and cirrhosis tissues. We found that eight genes that are specifically expressed in the endothelial cell and stellate cell of the HCC patients and correlated them with their survival rate, which may provide novel diagnosis and treatment targets for the clinical application.
肝细胞癌 (HCC) 的发生与慢性炎症密切相关，慢性炎症可导致肝纤维化和肝硬化，HCC 与微环境的相互作用进一步促进了肿瘤的发生。然而，目前缺乏单细胞分辨率的研究，这限制了我们对肝脏肿瘤生物学的分子理解。在这里，我们使用已发表的单细胞测序技术 (scRNA-seq) 数据库，以无偏倚的方式对肝微环境进行了高分辨率分析，并在 HCC 和肝硬化组织中对各种细胞群体和亚群的转录组进行了比较。我们发现了 8 个在 HCC 患者的内皮细胞和成纤维细胞中特异性表达的基因，并将其与患者的生存率相关联，这可能为临床应用提供新的诊断和治疗靶点。
