Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.
Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.
J Cutan Pathol. 2021 May;48(5):694-700. doi: 10.1111/cup.13974. Epub 2021 Feb 18.
Lymphomatoid papulosis (LyP) type E is a rare variant of the primary cutaneous CD30+ lymphoproliferative disorders, characterized clinically by large necrotic eschar-like lesions and histopathologically by angiodestructive and angioinvasive infiltrates of CD30+ lymphocytes. As in other forms of lymphomatoid papulosis, type E lesions may undergo spontaneous regression after weeks, with frequent recurrences. We report a 21-year old male with an angiodestructive infiltrate of CD30+ lymphocytes manifesting as a papular eruption rather than ulceration, and suggest that this clinical phenotype might be related to the presence of CD4+ lymphocytes in the inflammatory cell infiltrate.
蕈样肉芽肿病（LyP）E 型是一种罕见的原发性皮肤 CD30+淋巴增生性疾病的变异型，临床上表现为大的坏死性象皮样皮损，组织病理学上表现为 CD30+淋巴细胞的血管破坏性和血管侵袭性浸润。与其他蕈样肉芽肿病类型一样，E 型病变可在数周后自发消退，但常有复发。我们报告了一例 21 岁男性，其 CD30+淋巴细胞的血管破坏性浸润表现为丘疹性发疹而不是溃疡，我们推测这种临床表型可能与炎症细胞浸润中存在 CD4+淋巴细胞有关。
