双氢醇酸 A，一种新的具有 AChE 抑制活性的多手性倍半萜类化合物，来源于红树林来源的真菌 sp.

Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus sp.

机构信息

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

College of Earth and Planetary Science, University of Chinese Academy of Sciences, Beijing 100049, China.

出版信息

J Asian Nat Prod Res. 2022 Jan;24(1):88-95. doi: 10.1080/10286020.2021.1873297. Epub 2021 Feb 3.

DOI:10.1080/10286020.2021.1873297

PMID:33533666

Abstract

A new polychiral bisabolane sesquiterpene, bisabolanoic acid A (), was isolated from the mangrove-derived fungus sp. SCSIO KcB3-2. Its planar structure was identified on the basis of spectroscopic data analysis (HRESIMS, 1D, and 2D NMR), and the absolute configurations of three chiral carbons were determined by experimental and calculated electronic circular dichroism (ECD) and optical rotatory dispersion (ORD), together with Mo(OAc)-induced ECD methods. Bisabolanoic acid A () showed moderate inhibitory activity against acetylcholinesterase (AChE) with IC value of 2.2 μM, and the molecular docking was also performed.

摘要

从红树林来源的真菌 sp. SCSIO KcB3-2 中分离得到一种新的多手性倍半萜类化合物，倍半萜酸 A（）。基于光谱数据分析（HRESIMS、1D 和 2D NMR）确定了其平面结构，通过实验和计算的电子圆二色性（ECD）和旋光色散（ORD）以及 Mo(OAc)-诱导的 ECD 方法确定了三个手性碳的绝对构型。倍半萜酸 A（）对乙酰胆碱酯酶（AChE）表现出中等抑制活性，IC 值为 2.2 μM，还进行了分子对接。