Instituto Butantan, Centro de Farmacovigilância, Segurança Clínica e Gestão de Risco, São Paulo, São Paulo, Brazil.
Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Departamento de Clínica Médica, Botucatu, São Paulo, Brazil.
Rev Inst Med Trop Sao Paulo. 2021 Jan 29;63:e10. doi: 10.1590/S1678-9946202163010. eCollection 2021.
This cross-sectional seroepidemiological survey presents the seroprevalence of SARS-CoV-2 in a population living in 15 Long-Term Care Facilities (LTCFs), after two intra-institutional outbreaks of COVID-19 in the city of Botucatu, Sao Paulo State, Brazil. Residents were invited to participate in the serological survey performed in June and July 2020. Sociodemographic and clinical characterization of the participants as well as the LTCF profile were recorded. Blood samples were collected, processed and serum samples were tested using the rapid One Step COVID-19 immunochromatography test to detect IgM and IgG anti-SARS-CoV-2. Among 209 residents, the median of age was 81 years old, 135 (64.6%) were female and 171 (81.8%) self-referred as being white. An overall seroprevalence of 11.5% (95% CI: 7.5% - 16.6%) was found. The highest seroprevalences of 100% and 76.9% were observed in LTCFs that had experienced COVID-19 outbreaks. Most residents with positive immunochromatography tests (70.8%) referred previous contact with a confirmed COVID-19 case. Although there was a relatively low seroprevalence of COVID-19 in the total number of elderly people, this population is highly vulnerable and LTCFs are environments at higher risk for COVID-19 dissemination. A well-established test for COVID-19 policies, the adequate characterization of the level of interaction between residents and the healthcare provider team and the level of complexity of care are crucial to monitor and control the transmission of SARS-CoV-2 in these institutions.
本横断面血清流行病学调查呈现了巴西圣保罗州博图卡图市发生两起院内 COVID-19 疫情后，居住在 15 家长期护理机构（LTCF）的人群中 SARS-CoV-2 的血清流行率。邀请居民参加 2020 年 6 月至 7 月进行的血清学调查。记录了参与者的社会人口学和临床特征以及 LTCF 特征。采集血样，处理后使用快速一步法 COVID-19 免疫层析检测试剂盒检测血清样本中的 IgM 和 IgG 抗 SARS-CoV-2。在 209 名居民中，年龄中位数为 81 岁，135 名（64.6%）为女性，171 名（81.8%）自述为白人。总血清流行率为 11.5%（95%CI：7.5%-16.6%）。经历过 COVID-19 疫情爆发的 LTCF 的血清流行率最高，分别为 100%和 76.9%。免疫层析检测阳性的大多数居民（70.8%）自述曾与确诊的 COVID-19 病例有过接触。尽管在老年人总数中 COVID-19 的血清流行率相对较低，但该人群高度脆弱，LTCF 是 COVID-19 传播的高风险环境。制定完善的 COVID-19 政策检测、充分描述居民与医疗保健提供者团队之间的互动程度以及护理的复杂程度，对于监测和控制这些机构中 SARS-CoV-2 的传播至关重要。
