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低频电刺激对大鼠跟腱愈合影响的组织学评价。

Histological evaluation of the effect of low-frequency electric stimulation on healing Achilles tendons in rats.

机构信息

Fellow Master degree. Universidade Federal do Paraná - Postgraduate Program in Clinical Surgery - Curitiba (PR), Brazil.

.Full Professor. Universidade Federal do Paraná - Department of Surgery; and Permanent Professor. UniversidadeFederal do Paraná - Postgraduate Program in Clinical Surgery - Curitiba (PR), Brazil.

出版信息

Acta Cir Bras. 2021 Feb 1;36(1):e360103. doi: 10.1590/ACB360103. eCollection 2021.

DOI:10.1590/ACB360103
PMID:33533827
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7853699/
Abstract

PURPOSE

Histologically evaluate the effects of low frequency electrical stimulation in the treatment of Achilles tendon injuries in rats.

METHODS

Thirty-four rats underwent Achilles tendon tenotomy and tenorrhaphy. They were randomly allocated in two groups. Half of the sample constituted the experiment group, whose lesions were stimulated with 2 Hz, nonpolarized current and 1 mA, for 14 days. The other animals formed the control group. They were evaluated at 2, 4 and 6 weeks. The histological study was carried out, the collagen density and the wound maturity index were measured.

RESULTS

The healing score was higher in the group stimulated at the 6th week (p = 0.018). The density collagen 1 was higher in the group treated at the three times (p = 0.004) and that collagen 3 was higher in the group treated at 6 weeks (p = 0.004). Together, collagen 1 and 3 were higher in the group stimulated at 4 and 6 weeks (p = 0.009, p = 0.004). The maturity index was higher in this group at the three moments (p = 0.017 p = 0.004 and p = 0.009).

CONCLUSION

Low frequency electric stimulation improved healing and increased the quantity of collagen.

摘要

目的

从组织学角度评估低频电刺激治疗大鼠跟腱损伤的效果。

方法

34 只大鼠接受跟腱切断和修复术。将它们随机分配到两组。样本的一半构成实验组，其损伤部位用 2 Hz、非极化电流和 1 mA 刺激 14 天。另一些动物则构成对照组。在第 2、4 和 6 周对它们进行评估。进行组织学研究，测量胶原密度和伤口成熟指数。

结果

在第 6 周刺激组的愈合评分更高（p = 0.018）。在三次治疗中，胶原 1 的密度更高（p = 0.004），而在第 6 周治疗时，胶原 3 的密度更高（p = 0.004）。总的来说，在第 4 和第 6 周刺激组中，胶原 1 和胶原 3 的密度更高（p = 0.009，p = 0.004）。在这三个时间点，该组的成熟指数更高（p = 0.017，p = 0.004 和 p = 0.009）。

结论

低频电刺激可促进愈合并增加胶原的数量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/736dca757f41/1678-2674-acb-36-1-e360103-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/741ec3689ebf/1678-2674-acb-36-1-e360103-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/337f7d622494/1678-2674-acb-36-1-e360103-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/bf91a11355db/1678-2674-acb-36-1-e360103-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/8c974dea1078/1678-2674-acb-36-1-e360103-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/e7bf7f3e015b/1678-2674-acb-36-1-e360103-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/171a619acebc/1678-2674-acb-36-1-e360103-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/7b90b6a890ff/1678-2674-acb-36-1-e360103-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/736dca757f41/1678-2674-acb-36-1-e360103-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/741ec3689ebf/1678-2674-acb-36-1-e360103-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/337f7d622494/1678-2674-acb-36-1-e360103-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/bf91a11355db/1678-2674-acb-36-1-e360103-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/8c974dea1078/1678-2674-acb-36-1-e360103-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/e7bf7f3e015b/1678-2674-acb-36-1-e360103-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/171a619acebc/1678-2674-acb-36-1-e360103-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/7b90b6a890ff/1678-2674-acb-36-1-e360103-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5974/7853699/736dca757f41/1678-2674-acb-36-1-e360103-gf08.jpg

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