Pevsner J, Hwang P M, Sklar P B, Venable J C, Snyder S H
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2383-7. doi: 10.1073/pnas.85.7.2383.
Odorant-binding protein selectively binds various odorants and is discretely concentrated in nasal mucosa and secretions. We have localized rat odorant-binding protein mRNA to the lateral nasal gland by in situ hybridization histochemistry and have also localized the protein to this gland by immunohistochemistry and by tritiated-odorant autoradiography. The lateral nasal gland extends a long duct toward the external nares. Odorant-binding protein, released from this duct, may transport odorants to olfactory receptor neurons.
气味结合蛋白选择性地结合各种气味剂,并离散地集中在鼻黏膜和分泌物中。我们通过原位杂交组织化学将大鼠气味结合蛋白mRNA定位到外侧鼻腺,并且还通过免疫组织化学和氚标记气味剂放射自显影将该蛋白定位到该腺体。外侧鼻腺向鼻孔延伸出一条长导管。从这条导管释放的气味结合蛋白可能将气味剂转运到嗅觉受体神经元。