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气味结合蛋白及其mRNA定位于鼻侧腺，这意味着其具有载体功能。

Odorant-binding protein and its mRNA are localized to lateral nasal gland implying a carrier function.

作者信息

Pevsner J, Hwang P M, Sklar P B, Venable J C, Snyder S H

机构信息

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

出版信息

Proc Natl Acad Sci U S A. 1988 Apr;85(7):2383-7. doi: 10.1073/pnas.85.7.2383.

DOI:10.1073/pnas.85.7.2383
PMID:3353387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC279997/
Abstract

Odorant-binding protein selectively binds various odorants and is discretely concentrated in nasal mucosa and secretions. We have localized rat odorant-binding protein mRNA to the lateral nasal gland by in situ hybridization histochemistry and have also localized the protein to this gland by immunohistochemistry and by tritiated-odorant autoradiography. The lateral nasal gland extends a long duct toward the external nares. Odorant-binding protein, released from this duct, may transport odorants to olfactory receptor neurons.

摘要

气味结合蛋白选择性地结合各种气味剂，并离散地集中在鼻黏膜和分泌物中。我们通过原位杂交组织化学将大鼠气味结合蛋白mRNA定位到外侧鼻腺，并且还通过免疫组织化学和氚标记气味剂放射自显影将该蛋白定位到该腺体。外侧鼻腺向鼻孔延伸出一条长导管。从这条导管释放的气味结合蛋白可能将气味剂转运到嗅觉受体神经元。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/ddabe381f1b2/pnas00259-0369-e.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/7d71b32ad25e/pnas00259-0367-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/fb3838fad3d4/pnas00259-0367-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/0a75e096e757/pnas00259-0367-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/65574d2e031b/pnas00259-0367-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/dd2e380b7c4b/pnas00259-0367-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/de49722b37a8/pnas00259-0367-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/e645e5882379/pnas00259-0368-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/6b0478c41fbd/pnas00259-0369-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/8c4aacb94658/pnas00259-0369-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96d/279997/933bd3b6f0a4/pnas00259-0369-c.jpg
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本文引用的文献

1
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Ann Otol Rhinol Laryngol. 1965 Jun;74:363-75. doi: 10.1177/000348946507400207.
2
TOPOGRAPHY OF THE NASAL GLANDS IN RATS AND SOME OTHER MAMMALS.大鼠及其他一些哺乳动物鼻腺的局部解剖学
Anat Rec. 1964 Sep;150:11-24. doi: 10.1002/ar.1091500103.
3
Hamster nasal glands: their structure, sialic acid content, and vulnerability to actinomycin D.
J Morphol. 1982 Oct;174(1):79-94. doi: 10.1002/jmor.1051740107.
感觉器官顶细胞外基质的特殊结构和功能。
Cells Dev. 2024 Sep;179:203942. doi: 10.1016/j.cdev.2024.203942. Epub 2024 Jul 25.
4
A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation.鼻腔细胞图谱揭示了微绒毛细胞的异质性及其在指导嗅干细胞增殖中的作用。
Sci Immunol. 2024 Feb 2;9(92):eabq4341. doi: 10.1126/sciimmunol.abq4341.
5
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health.新冠病毒感染相关嗅觉功能障碍：发病机制及对大脑健康的长期影响。
Trends Mol Med. 2022 Sep;28(9):781-794. doi: 10.1016/j.molmed.2022.06.005. Epub 2022 Jun 20.
6
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Genome Biol Evol. 2021 Jun 8;13(6). doi: 10.1093/gbe/evab091.
7
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Expression of odorant-binding proteins in mouthpart palps of the desert locust Schistocerca gregaria.表达气味结合蛋白在沙漠蝗Schistocerca gregaria 口器触角中的作用。
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