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评估溶质载体（SLC）家族 39 基因对肺腺癌患者的预后价值。

Evaluation of the prognostic values of solute carrier (SLC) family 39 genes for patients with lung adenocarcinoma.

机构信息

Department of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, P. R. China.

Department of Stomatology, TaikangTongji Hospital, Wuhan 430000, Hubei Province, P. R. China.

出版信息

Aging (Albany NY). 2021 Feb 1;13(4):5312-5331. doi: 10.18632/aging.202452.

DOI:10.18632/aging.202452
PMID:33535184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7950255/
Abstract

BACKGROUND

Lung cancer is the first fatality rate of cancer-related death worldwide. This study aimed to evaluate the solute carrier family 39 (SLC39A) genes as biological markers associated with the prognosis of lung adenocarcinoma (LUAD).

METHODS AND MATERIALS

MRNA expression of SLC39A genes in non-small cell lung cancer (NSCLC) was analyzed using UCSC database. We investigated the overall survival (OS) of SLC39A genes in patients with NSCLC as the only prognostic indicator using the Kaplan-Meier plotter. CERES score obtained from the Project Achilles was used to perform the survival analysis. Crystal violet-glutaraldehyde solution staining and CCK-8 assay were used to determine colony formation and cell viability, respectively.

RESULTS

For patients with lung squamous cell carcinoma, only high expression of SLC39A3, SLC39A4 and SLC39A7 have significant affections to the prognosis. But for patients with LUAD, 11 out of 14 SLC39A genes were significantly associated with prognostic values. Additional analysis indicated that SLC39A7 played an essential role for cell survival of LUAD. Furthermore, SLC39A7 high expression in LUAD was associated with current smoking.

CONCLUSIONS

Our findings indicated that SLC39A groups were significantly associated with prognosis of LUAD. The SLC39A7 gene was significantly linked with survival and growth of LUAD cells.

摘要

背景

肺癌是全球癌症相关死亡的首要致死率。本研究旨在评估溶质载体家族 39（SLC39A）基因作为与肺腺癌（LUAD）预后相关的生物标志物。

方法和材料

使用 UCSC 数据库分析非小细胞肺癌（NSCLC）中 SLC39A 基因的 mRNA 表达。我们使用 Kaplan-Meier plotter 作为唯一的预后指标，研究 SLC39A 基因在 NSCLC 患者中的总体生存率（OS）。使用 Achilles 项目中的 CERES 评分进行生存分析。结晶紫-戊二醛溶液染色和 CCK-8 测定分别用于测定集落形成和细胞活力。

结果

对于肺鳞癌患者，只有 SLC39A3、SLC39A4 和 SLC39A7 的高表达对预后有显著影响。但对于 LUAD 患者，14 个 SLC39A 基因中有 11 个与预后值显著相关。进一步的分析表明，SLC39A7 对 LUAD 细胞的存活起着至关重要的作用。此外，LUAD 中 SLC39A7 的高表达与当前吸烟有关。

结论

我们的研究结果表明，SLC39A 基因与 LUAD 的预后显著相关。SLC39A7 基因与 LUAD 细胞的存活和生长显著相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/d74955015905/aging-13-202452-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/a180acff4496/aging-13-202452-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/356f802bbe2e/aging-13-202452-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/90721d311984/aging-13-202452-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/b0a9ec60cc3d/aging-13-202452-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/48d8f61469a5/aging-13-202452-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/7195e114f74f/aging-13-202452-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/d74955015905/aging-13-202452-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/a180acff4496/aging-13-202452-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/356f802bbe2e/aging-13-202452-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/90721d311984/aging-13-202452-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/b0a9ec60cc3d/aging-13-202452-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/48d8f61469a5/aging-13-202452-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/7195e114f74f/aging-13-202452-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4b4/7950255/d74955015905/aging-13-202452-g007.jpg

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