间充质干细胞减轻放疗副作用。
Mesenchymal Stem Cells for Mitigating Radiotherapy Side Effects.
机构信息
School of Medical Technology, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou Medical University, Xuzhou City 221004, China.
Division of Cardiology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang City 212132, China.
出版信息
Cells. 2021 Feb 1;10(2):294. doi: 10.3390/cells10020294.
Abstract
Radiation therapy for cancers also damages healthy cells and causes side effects. Depending on the dosage and exposure region, radiotherapy may induce severe and irreversible injuries to various tissues or organs, especially the skin, intestine, brain, lung, liver, and heart. Therefore, promising treatment strategies to mitigate radiation injury is in pressing need. Recently, stem cell-based therapy generates great attention in clinical care. Among these, mesenchymal stem cells are extensively applied because it is easy to access and capable of mesodermal differentiation, immunomodulation, and paracrine secretion. Here, we summarize the current attempts and discuss the future perspectives about mesenchymal stem cells (MSCs) for mitigating radiotherapy side effects.
摘要
癌症的放射疗法也会损害健康细胞并引起副作用。根据剂量和照射区域的不同，放射疗法可能会对各种组织或器官（尤其是皮肤、肠道、大脑、肺、肝和心脏）造成严重且不可逆转的损伤。因此，迫切需要有前途的治疗策略来减轻辐射损伤。最近，基于干细胞的疗法在临床护理中引起了广泛关注。在这些方法中，间充质干细胞的应用非常广泛，因为它易于获取，并且能够向中胚层分化、免疫调节和旁分泌。在这里，我们总结了目前的尝试，并讨论了间充质干细胞（MSCs）减轻放射治疗副作用的未来前景。
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