Chao Chien-Liang, Huang Hsin-Wen, Su Muh-Hwan, Lin Hang-Ching, Wu Wen-Mein
Sinphar Pharmaceutical Co., Ltd., Sinphar Group, Yilan 269, Taiwan.
School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan.
Life (Basel). 2021 Feb 1;11(2):111. doi: 10.3390/life11020111.
(Schwein) F.A. Wolf (syn. ) dried sclerotium, called fuling, is an edible, saprophytic fungus commonly used as a tonic and anti-aging traditional Chinese medicine. It is traditionally used in combination with other traditional Chinese medicines to enhance immunity. This study showed that extract (Lipucan) containing lanostane triterpenoids has no immunotoxicity and enhances non-specific (innate) immunity though activating natural killer cells and promotes interferon γ (IFN-γ) secretion by Type 1 T-helper (Th1) cells immune response. In addition, extract significantly decreased interleukin (IL-4 and IL-5) secretion by Type 2 T-helper (Th2) cells immune response, which are related to the allergy response. The purified lanostane triterpenoids were first identified as active ingredients of with enhanced non-specific immunity by promoting interferon γ (IFN-γ) secretion in a preliminary study. Our findings support that the extract plays beneficial roles in immunoregulatory activity.
茯苓（猪苓）干燥菌核，传统上称为茯苓，是一种可食用的腐生真菌，常用于滋补和抗衰老的传统中药。传统上它与其他中药联合使用以增强免疫力。本研究表明，含有羊毛甾烷三萜类化合物的提取物（力扑素）无免疫毒性，通过激活自然杀伤细胞增强非特异性（固有）免疫力，并促进1型辅助性T细胞（Th1）免疫反应分泌干扰素γ（IFN-γ）。此外，该提取物显著降低了与过敏反应相关的2型辅助性T细胞（Th2）免疫反应分泌的白细胞介素（IL-4和IL-5）。在一项初步研究中，纯化的羊毛甾烷三萜类化合物首次被鉴定为茯苓增强非特异性免疫力的活性成分。我们的研究结果支持茯苓提取物在免疫调节活性中发挥有益作用。
