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Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.

作者信息

Crosby L D, Kalanidhi S, Bonilla A, Subramanian A, Ballon J S, Bonilla H

机构信息

Stanford University School of Medicine, Stanford, USA.

University of Michigan, College of Literature, Sciences, and Arts, Ann Arbor, MI, USA.

出版信息

J Transl Med. 2021 Feb 3;19(1):50. doi: 10.1186/s12967-021-02721-9.

DOI:10.1186/s12967-021-02721-9
PMID:33536023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7860172/
Abstract
摘要

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Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.阿立哌唑的非标签使用显示出作为治疗肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的潜力：一项对101例接受低剂量阿立哌唑治疗患者的回顾性研究。
J Transl Med. 2021 Feb 3;19(1):50. doi: 10.1186/s12967-021-02721-9.
2
Publisher Correction to: Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.《阿立哌唑的非标签使用显示出作为肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）治疗方法的前景：对101例接受低剂量阿立哌唑治疗患者的回顾性研究》的出版商更正
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本文引用的文献

1
Cytokine signature associated with disease severity in chronic fatigue syndrome patients.与慢性疲劳综合征患者疾病严重程度相关的细胞因子特征。
Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7150-E7158. doi: 10.1073/pnas.1710519114. Epub 2017 Jul 31.
2
Aripiprazole-induced adverse metabolic alterations in polyI:C neurodevelopmental model of schizophrenia in rats.阿立哌唑诱导的精神分裂症多聚 I:C 神经发育模型大鼠代谢不良改变。
Neuropharmacology. 2017 Sep 1;123:148-158. doi: 10.1016/j.neuropharm.2017.06.003.
3
Therapeutic effect of aripiprazole in chronic schizophrenia is accompanied by anti-inflammatory activity.
肌痛性脑脊髓炎/慢性疲劳综合征中的认知功能障碍——病因及潜在治疗方法
Int J Mol Sci. 2025 Feb 22;26(5):1896. doi: 10.3390/ijms26051896.
4
Chronic inflammatory response syndrome: a review of the evidence of clinical efficacy of treatment.慢性炎症反应综合征：治疗临床疗效证据综述
Ann Med Surg (Lond). 2024 Nov 8;86(12):7248-7254. doi: 10.1097/MS9.0000000000002718. eCollection 2024 Dec.
5
Developing a clinical-pathological framework of long COVID-related fatigue applied to public safety workers.建立适用于公共安全工作者的长新冠相关疲劳的临床病理框架。
Front Med (Lausanne). 2024 Jul 17;11:1387499. doi: 10.3389/fmed.2024.1387499. eCollection 2024.
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[Interdisciplinary, collaborative D-A-CH (Germany, Austria and Switzerland) consensus statement concerning the diagnostic and treatment of myalgic encephalomyelitis/chronic fatigue syndrome].[关于肌痛性脑脊髓炎/慢性疲劳综合征诊断与治疗的跨学科、协作性德奥瑞（德国、奥地利和瑞士）共识声明]
Wien Klin Wochenschr. 2024 Aug;136(Suppl 5):103-123. doi: 10.1007/s00508-024-02372-y. Epub 2024 May 14.
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Front Immunol. 2024 Apr 8;15:1369295. doi: 10.3389/fimmu.2024.1369295. eCollection 2024.
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Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders.神经炎症和神经退行性疾病的最新研究趋势。
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Biomolecules. 2023 Jun 26;13(7):1039. doi: 10.3390/biom13071039.
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Fighting Post-COVID and ME/CFS - development of curative therapies.对抗新冠后遗症和肌痛性脑脊髓炎/慢性疲劳综合征——治愈性疗法的研发
Front Med (Lausanne). 2023 Jun 15;10:1194754. doi: 10.3389/fmed.2023.1194754. eCollection 2023.
阿立哌唑治疗慢性精神分裂症的疗效伴有抗炎活性。
Pharmacol Rep. 2015 Apr;67(2):353-9. doi: 10.1016/j.pharep.2014.09.007. Epub 2014 Sep 26.
4
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.多巴胺通过抑制 NLRP3 炎性小体来控制全身炎症。
Cell. 2015 Jan 15;160(1-2):62-73. doi: 10.1016/j.cell.2014.11.047.
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Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.慢性疲劳综合征/肌痛性脑脊髓炎患者的神经炎症：¹¹C-(R)-PK11195 PET 研究。
J Nucl Med. 2014 Jun;55(6):945-50. doi: 10.2967/jnumed.113.131045. Epub 2014 Mar 24.