Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Vet Med Sci. 2022 Nov;8(6):2738-2772. doi: 10.1002/vms3.912. Epub 2022 Aug 29.
The existing drug treatments for trypanosomiases are limited and suffer from shortcomings due to their toxicity and the emergence of resistant parasites. Developing anti-trypanosomal compounds based on natural products is a promising way of fighting trypanosomiases.
This study aims to identify through scientific review a large variety of medicinal plants (anti-trypanosomal) used worldwide and scientifically shown to display anti-trypanosomal effects.
To collect data, the anti-trypanosomal activities of Africa, Asia, the Middle East, South America, North America, Europe and Oceania medicinal plants have been checked by considering the published paper.
Based on collected data, 77 natural molecules were reported in the literature. Of which 59 were from the African region, 11 from Asia, 3 from Europe and 4 from Latin America. These active components belong to alkaloids, triterpenoids, lactone, quinoids, flavonoids, iridoids, lignans, steroids, lipids, oxygenated heterocycles, benzenoids, proteins, coumarins, phenylpropanoids and peptides. We also specified the prosperous plants with unique anti-trypanosomal activities.
However, there is a need for further studies on the ability of the isolated compounds to ameliorate the trypanosome-induced pathological alterations and also the elucidation of their modes of actions and activities against other trypanosome species.
现有的抗锥虫病药物治疗方法有限，并且由于其毒性和寄生虫耐药性的出现而存在缺陷。基于天然产物开发抗锥虫化合物是对抗锥虫病的一种有前途的方法。
本研究旨在通过科学综述，确定在世界范围内广泛使用的、经科学证明具有抗锥虫作用的药用植物（抗锥虫）。
为了收集数据，通过查阅已发表的论文，检查了非洲、亚洲、中东、南美洲、北美洲、欧洲和大洋洲药用植物的抗锥虫活性。
根据收集的数据，文献中报道了 77 种天然分子。其中 59 种来自非洲地区，11 种来自亚洲，3 种来自欧洲，4 种来自拉丁美洲。这些活性成分属于生物碱、三萜、内酯、醌、类黄酮、环烯醚萜、木脂素、甾体、脂类、含氧杂环、苯并呋喃、蛋白质、香豆素、苯丙素和肽。我们还特别指出了具有独特抗锥虫活性的繁荣植物。
然而，仍需要进一步研究分离化合物改善锥虫引起的病理改变的能力，以及阐明它们的作用模式和对其他锥虫物种的活性。
