Mothes-Luksch N, Raith M, Stingl G, Focke-Tejkl M, Razzazi-Fazeli E, Zieglmayer R, Wöhrl S, Swoboda I
Comparative Immunology and Oncology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Molecular Biotechnology Section, FH Campus Wien, University of Applied Sciences, Campus Vienna Biocenter, Vienna, Austria.
Allergy. 2017 Sep;72(9):1415-1418. doi: 10.1111/all.13151. Epub 2017 Apr 3.
In the Mediterranean area, lipid transfer proteins (LTPs) are important causes of plant-food allergies often associated with severe allergic reactions. There, peach LTP (Pru p 3) seems to be the primary sensitizer, whereas in Central Europe, little is known about the importance of LTP sensitization. In this region, allergen extract-based diagnosis is often complicated by co-sensitization to Bet v 1, the major birch pollen allergen, its cross-reactive food allergens, and profilins. We investigated the role of LTP sensitization in Central European patients displaying strong allergic reactions to plant-derived food. Analysis of IgE reactivity revealed that ten of thirteen patients were sensitized to Pru p 3, nine to Bet v 1, and two to profilin. Our results showed that LTP sensitization represents a risk factor for severe allergic symptoms in Central Europe. Furthermore, the strong IgE reactivity detected in immunoblots of plant-food extracts indicated that Pru p 3 can be used as a marker allergen for LTP sensitization also in Central European patients.
在地中海地区，脂质转移蛋白（LTPs）是植物性食物过敏的重要原因，常与严重过敏反应相关。在那里，桃脂质转移蛋白（Pru p 3）似乎是主要的致敏原，而在中欧，关于脂质转移蛋白致敏的重要性知之甚少。在该地区，基于变应原提取物的诊断常常因对主要桦树花粉变应原Bet v 1、其交叉反应性食物变应原以及肌动蛋白结合蛋白的共同致敏而变得复杂。我们调查了脂质转移蛋白致敏在对植物源性食物有强烈过敏反应的中欧患者中的作用。IgE反应性分析显示，13名患者中有10名对Pru p 3致敏，9名对Bet v 1致敏，2名对肌动蛋白结合蛋白致敏。我们的结果表明，脂质转移蛋白致敏是中欧严重过敏症状的一个危险因素。此外，在植物性食物提取物免疫印迹中检测到的强烈IgE反应性表明，Pru p 3也可作为中欧患者脂质转移蛋白致敏的标记变应原。
