Kirisawa Takahiro, Ichihara Koji, Sakai Yasuyuki, Morooka Daichi, Iyoki Takaya, Masumori Naoya
Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Sex Med. 2021 Apr;9(2):100306. doi: 10.1016/j.esxm.2020.100306. Epub 2021 Feb 1.
The evidence on gender-affirming hormonal treatment (HT) for transgender persons is still insufficient.
To characterize the physical and psychological effects of HT using testosterone enanthate in transgender men, and to validate the safety of this treatment.
A total of 85 Japanese transgender men who were followed up for at least 1 year at our gender clinic from 2004 to 2017 were included in this study. All self-reported effects that they recognized and regularly acquired laboratory data were investigated after initiation of HT.
HT mainly using testosterone enanthate 250 mg every 2 weeks caused the most desired physical effects to appear promptly and effectively, whereas small but not negligible numbers of undesired physical and psychological effects were also confirmed.
The initial dose of testosterone enanthate was 250 mg for 72 (84.7%) subjects, and the injection interval was maintained every 2 weeks for 70 (82.3%). Most physical effects appeared within 6 months. A deepened voice (87.1%), cessation of menses (78.8%), acne (69.4%), and facial (52.9%)/body (37.6%) hair growth occurred within 3 months. Although recognition of psychological effects was rare, emotional instability (9.4%) and increased libido (7.1%) appeared in the relatively early phase after beginning HT. The mean values for red blood cells, hemoglobin, uric acid, and alkaline phosphatase were significantly increased for 2 year. During the observation period, there were no life-threatening adverse effects in any subjects.
The present HT strategy is effective and safe for Japanese transgender men. The information from self-reported effects and objective data from blood tests can help both physicians and transgender men to understand testosterone HT. Kirisawa T, Ichihara K, Sakai Y, et al. Physical and Psychological Effects of Gender-Affirming Hormonal Treatment Using Intramuscular Testosterone Enanthate in Japanese Transgender Men. Sex Med 2021;9:100306.
关于跨性别者性别确认激素治疗（HT）的证据仍然不足。
描述使用庚酸睾酮对跨性别男性进行HT的生理和心理影响，并验证这种治疗的安全性。
本研究纳入了2004年至2017年期间在我们性别诊所接受至少1年随访的85名日本跨性别男性。在开始HT后，对他们自我报告的所有已认识到的影响以及定期获取的实验室数据进行了调查。
主要使用每2周250mg庚酸睾酮的HT能迅速有效地产生最期望的生理效果，不过也证实了少量但并非可以忽略不计的不良生理和心理影响。
72名（84.7%）受试者的庚酸睾酮初始剂量为250mg，70名（82.3%）的注射间隔维持每2周一次。大多数生理影响在6个月内出现。3个月内出现声音变低沉（87.1%）、月经停止（78.8%）、痤疮（69.4%）以及面部（52.9%）/身体（37.6%）毛发增多。虽然对心理影响的认识很少见，但在开始HT后的相对早期出现了情绪不稳定（9.4%）和性欲增强（7.1%）。红细胞、血红蛋白、尿酸和碱性磷酸酶的平均值在2年内显著升高。在观察期内，所有受试者均未出现危及生命的不良反应。
目前的HT策略对日本跨性别男性是有效且安全的。自我报告的影响信息和血液检测的客观数据有助于医生和跨性别男性了解睾酮HT。桐泽T、市原K、酒井Y等。日本跨性别男性使用肌肉注射庚酸睾酮进行性别确认激素治疗的生理和心理影响。性医学2021；9：100306。
