Piras Cristian, Tilocca Bruno, Castagna Fabio, Roncada Paola, Britti Domenico, Palma Ernesto
Department of Health Sciences, "Magna Græcia University" of Catanzaro, Campus Universitario "Salvatore Venuta" Viale Europa, 88100 Catanzaro, Italy.
Interdepartmental Center Veterinary Service for Human and Animal Health, "Magna Græcia University" of Catanzaro, CISVetSUA, Campus Universitario "Salvatore Venuta" Viale Europa, 88100 Catanzaro, Italy.
Antibiotics (Basel). 2022 Jul 8;11(7):919. doi: 10.3390/antibiotics11070919.
Drug resistance threatening humans may be linked with antimicrobial and anthelmintic resistance in other species, especially among farm animals and, more in general, in the entire environment. From this perspective, Green Veterinary Pharmacology was proven successful for the control of parasites in small ruminants and for the control of other pests such as varroa in bee farming. As in anthelmintic resistance, antimicrobial resistance (AMR) represents one of the major challenges against the successful treatment of infectious diseases, and antimicrobials use in agriculture contributes to the spread of more AMR bacterial phenotypes, genes, and proteins. With this systematic review, we list Italian plants with documented antimicrobial activity against possible pathogenic microbes. Methods: The literature search included all the manuscripts published since 1990 in PubMed, Web of Science, and Scopus using the keywords (i) "antimicrobial, plants, Italy"; (ii) "antibacterial, plant, Italy"; (iii) "essential oil, antibacterial, Italy"; (iv) "essential oil, antimicrobial, Italy"; (v) "methanol extract, antibacterial, Italy"; (vi) "methanol extract, antimicrobial, Italy". Results: In total, 105 manuscripts that documented the inhibitory effect of plants growing in Italy against bacteria were included. One hundred thirty-five plants were recorded as effective against Gram+ bacteria, and 88 against Gram-. This will provide a ready-to-use comprehensive tool to be further tested against the indicated list of pathogens and will suggest new alternative strategies against bacterial pathogens to be employed in Green Veterinary Pharmacology applications.
威胁人类的耐药性可能与其他物种（尤其是农场动物，更广泛地说，在整个环境中）的抗微生物和抗寄生虫耐药性有关。从这个角度来看，绿色兽医药理学已被证明在控制小型反刍动物的寄生虫以及控制养蜂业中的其他害虫（如蜂螨）方面取得了成功。与抗寄生虫耐药性一样，抗菌药物耐药性（AMR）是成功治疗传染病面临的主要挑战之一，农业中抗菌药物的使用促成了更多AMR细菌表型、基因和蛋白质的传播。通过这项系统综述，我们列出了对可能的致病微生物具有抗菌活性记录的意大利植物。方法：文献检索包括自1990年以来在PubMed、科学网和Scopus上发表的所有手稿，使用的关键词为：（i）“抗菌、植物、意大利”；（ii）“抗菌、植物、意大利”；（iii）“精油、抗菌、意大利”；（iv）“精油、抗微生物、意大利”；（v）“甲醇提取物、抗菌、意大利”；（vi）“甲醇提取物、抗微生物、意大利”。结果：总共纳入了105篇记录意大利生长的植物对细菌抑制作用的手稿。记录到135种植物对革兰氏阳性菌有效，88种对革兰氏阴性菌有效。这将提供一个随时可用的综合工具，以便针对指定的病原体列表进行进一步测试，并将提出在绿色兽医药理学应用中对抗细菌病原体的新替代策略。
