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基于科学的公共政策:新冠疫情在随机试验应用方面的经验教训。

Science based public policies: Lessons from Covid19 on the use of randomized trials.

作者信息

Taschner Natalia Pasternak, Orsi Carlos

机构信息

Instituto Questão de Ciência, São Paulo, SP, Brazil.

Universidade de São Paulo, Instituto de Ciências Biomédicas, SP, Brazil.

出版信息

Genet Mol Biol. 2021 Jan 20;44(1 Suppl 1):e20200273. doi: 10.1590/1678-4685-GMB-2020-0273. eCollection 2021.

Abstract

The current SARS-CoV-2 pandemic gave rise to a spirit of methodological anarchy in some fronts of biomedical research, embraced by some under the excuses of urgency and time restraints. This movement, however, comes at the same time when social sciences begin to recognize the value and soundness of the clinical research rationale - the need for randomization, of fair comparisons between intervention groups, the humility of acknowledging ignorance and accepting uncertainty, these last two imperatives usually subsumed under the principle of "equipoise".

摘要

当前的新冠疫情在生物医学研究的某些领域引发了一种方法上的无政府主义思潮,一些人以紧迫性和时间限制为借口予以接受。然而,与此同时,社会科学开始认识到临床研究基本原理的价值和合理性——随机化的必要性、干预组之间进行公平比较的必要性、承认无知和接受不确定性的谦逊态度,最后这两点通常包含在“ equipoise”原则之下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9a/7876434/87faeec129ef/1415-4757-GMB-44-1-s1-e20200273-gf1.jpg

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