Division of Endocrinology, Metabolism and Diabetes, Hippocratio General Hospital, 11527 Athens, Greece.
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Nutrients. 2021 Feb 3;13(2):498. doi: 10.3390/nu13020498.
Obesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflammation may influence hypothalamic inter-connections with regions important for cognition and mood, while it may cause dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and influence monoaminergic systems. Exercise, healthy diet, and glucagon-like peptide receptor agonists, which can reduce hypothalamic inflammation in obese models, could improve the deleterious effects on cognition and mood.
肥胖通常与认知和情绪障碍有关。最近的证据表明，肥胖可能导致下丘脑炎症。我们的目的是研究肥胖引起的下丘脑炎症与认知和情绪障碍之间是否存在因果关系的假说。炎症可能会影响下丘脑与认知和情绪重要区域的连接，同时也可能导致下丘脑-垂体-肾上腺 (HPA) 轴的失调，并影响单胺能系统。运动、健康饮食和胰高血糖素样肽受体激动剂可以减少肥胖模型中的下丘脑炎症，从而改善对认知和情绪的不良影响。
