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2020 年越南暴发块状皮肤病疫情。

Lumpy skin disease outbreaks in vietnam, 2020.

机构信息

Department of Biochemistry and Immunology, National Institute of Veterinary Research, Hanoi, Vietnam.

出版信息

Transbound Emerg Dis. 2021 May;68(3):977-980. doi: 10.1111/tbed.14022. Epub 2021 Feb 21.

Abstract

Lumpy skin disease (LSD) is a transboundary, systemic, viral disease of cattle. The first outbreaks of LSD were reported in Lang Son Province of Vietnam (bordered to China), and an official document has been submitted to OIE on 1 November 2020. Here, we described first the genetic profiles of this pathogen based on four well-known marker regions. The LSD virus isolated in these first outbreaks was 100% identical to viruses isolated in China (2019) based on the p32 and RP030 genes. Additionally, it is very close to the virus isolated in Russia (2017) based on the p32, RP030, thymidine kinase and ORF103 genes (100%, 99.01%, 99.08% and 99.47% identities). This finding is new, and a success in LSD virus isolation using MDBK cells from first outbreaks is important for vaccine development to control and eradicate LSD in Vietnam.

摘要

牛结节疹病(LSD)是一种具有传染性、系统性的牛病毒性疾病。该病的首次爆发报告于越南谅山省(与中国接壤),并于 2020 年 11 月 1 日向 OIE 提交了正式文件。在此,我们基于四个知名标记区域,首次描述了该病原体的遗传特征。这些首次爆发中分离出的 LSD 病毒,与中国(2019 年)分离出的病毒在 p32 和 RP030 基因上完全一致。此外,它与俄罗斯(2017 年)分离出的病毒在 p32、RP030、胸苷激酶和 ORF103 基因上非常接近(100%、99.01%、99.08%和 99.47%的同一性)。这一发现是新的,首次从爆发中使用 MDBK 细胞分离出 LSD 病毒,这对于越南控制和根除 LSD 的疫苗开发具有重要意义。

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