Division of Plastic, Maxillofacial, and Oral Surgery, Department of Surgery, Duke University Health System, Durham, North Carolina.
Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.
J Reconstr Microsurg. 2021 Jul;37(6):530-540. doi: 10.1055/s-0041-1724465. Epub 2021 Feb 6.
Psychosocial distress, depression, or anxiety can occur in up to 50% of women after a breast cancer diagnosis and mastectomy. The purpose of this study was to assess the potential benefit of lavender oil as a perioperative adjunct to improve anxiety, depression, pain, and sleep in women undergoing microvascular breast reconstruction.
This was a prospective, single-blinded, randomized, controlled trial of 49 patients undergoing microvascular breast reconstruction. Patients were randomized to receive lavender oil or placebo (coconut oil) throughout their hospitalization. The effect of lavender oil on perioperative stress, anxiety, depression, sleep, and pain was measured using the hospital anxiety and depression scale, Richards-Campbell Sleep Questionnaire, and the visual analogue scale.
Twenty-seven patients were assigned to the lavender group and 22 patients were assigned to the control group. No significant differences were seen in the perioperative setting between the groups with regard to anxiety ( = 0.82), depression ( = 0.21), sleep ( = 0.86), or pain ( = 0.30) scores. No adverse events (i.e., allergic reaction) were captured, and no significant differences in surgery-related complications were observed. When evaluating the entire cohort, postoperative anxiety scores were significantly lower than preoperative scores ( < 0.001), while depression scores were significantly higher postoperatively as compared with preoperatively ( = 0.005).
In the setting of microvascular breast reconstruction, lavender oil and aromatherapy had no significant adverse events or complications; however, there were no measurable advantages pertaining to metrics of depression, anxiety, sleep, or pain as compared with the control group.
乳腺癌诊断和乳房切除术后，多达 50%的女性可能会出现心理困扰、抑郁或焦虑。本研究旨在评估薰衣草油作为围手术期辅助手段的潜在益处，以改善行微血管乳房重建术的女性的焦虑、抑郁、疼痛和睡眠。
这是一项前瞻性、单盲、随机、对照试验，纳入 49 例行微血管乳房重建术的患者。患者在住院期间随机接受薰衣草油或安慰剂（椰子油）治疗。采用医院焦虑抑郁量表、Richards-Campbell 睡眠问卷和视觉模拟量表评估薰衣草油对围手术期应激、焦虑、抑郁、睡眠和疼痛的影响。
27 例患者被分配至薰衣草组，22 例患者被分配至对照组。两组在围手术期的焦虑评分（ = 0.82）、抑郁评分（ = 0.21）、睡眠评分（ = 0.86）和疼痛评分（ = 0.30）方面无显著差异。未发现不良事件（即过敏反应），手术相关并发症也无显著差异。评估整个队列时，术后焦虑评分显著低于术前评分（ < 0.001），而抑郁评分术后显著高于术前（ = 0.005）。
在微血管乳房重建术中，薰衣草油和芳香疗法无显著不良事件或并发症；然而，与对照组相比，在抑郁、焦虑、睡眠或疼痛等指标方面，薰衣草油并无明显优势。
