Hülsemann J, Wember T, Kordass U, Sander G, Schmidt E, Schöch G
Forschungsinstitut für Kinderernährung, Dortmund, FRG.
Ann Nutr Metab. 1988;32(1):38-43. doi: 10.1159/000177390.
3-Methylhistidine and creatinine concentrations were determined in 45 24-hour urine samples collected in 380 single voidings from 23 preterm infants (gestational age: 30-36 weeks, median: 33 weeks; birth weight: 1,613 +/- 219 g; age: 9-83 days postpartum) and from 7 infants small for gestational age (birth weight: 2,061 +/- 203 g; age: 2-30 days postpartum). Statistical analysis shows that diurnal variations of the ratio 3-methylhistidine/creatinine are negligible. The variability of this ratio is chiefly caused by differences in excretion on different collection dates and is probably due to differences in the metabolic state. Hence the determination of 3-methylhistidine/creatinine ratio in single voidings is sufficient even in low-birth-weight infants. In our collective the mean 3-methylhistidine/creatinine ratio for healthy, well-growing low-birth-weight infants (n = 21) was 19.6 +/- 2.3 mumol/mmol. Infants with stagnating or decreasing weight (n = 5) showed 3-methylhistidine/creatinine ratios clearly above that of the normal group.
测定了23名早产儿（胎龄：30 - 36周，中位数：33周；出生体重：1613±219g；年龄：出生后9 - 83天）和7名小于胎龄儿（出生体重：2061±203g；年龄：出生后2 - 30天）单次排尿收集的45份24小时尿液样本中的3 - 甲基组氨酸和肌酐浓度。统计分析表明，3 - 甲基组氨酸/肌酐比值的昼夜变化可忽略不计。该比值的变异性主要由不同收集日期的排泄差异引起，可能是由于代谢状态的差异。因此，即使在低体重婴儿中，单次排尿中3 - 甲基组氨酸/肌酐比值的测定也足够了。在我们的研究对象中，健康、生长良好的低体重婴儿（n = 21）的平均3 - 甲基组氨酸/肌酐比值为19.6±2.3μmol/mmol。体重停滞或下降的婴儿（n = 5）的3 - 甲基组氨酸/肌酐比值明显高于正常组。
