Huang Fengtao, Zhu Bin
Key Laboratory of Molecular Biophysics, the Ministry of Education, College of Life Science and Technology and Shenzhen College, Huazhong University of Science and Technology, Wuhan, China.
Front Microbiol. 2021 Jan 20;11:602789. doi: 10.3389/fmicb.2020.602789. eCollection 2020.
Type III CRISPR-Cas systems, which are widespread in both bacteria and archaea, provide immunity against DNA viruses and plasmids in a transcription-dependent manner. Since an unprecedented cyclic oligoadenylate (cOA) signaling pathway was discovered in type III systems in 2017, the cOA signaling has been extensively studied in recent 3 years, which has expanded our understanding of type III systems immune defense and also its counteraction by viruses. In this review, we summarized recent advances in cOA synthesis, cOA-activated effector protein, cOA signaling-mediated immunoprotection, and cOA signaling inhibition, and highlighted the crosstalk between cOA signaling and other cyclic oligonucleotide-mediated immunity discovered very recently.
III型CRISPR-Cas系统广泛存在于细菌和古生菌中，以转录依赖的方式提供针对DNA病毒和质粒的免疫。自2017年在III型系统中发现前所未有的环状寡腺苷酸（cOA）信号通路以来，近3年对cOA信号进行了广泛研究，这扩展了我们对III型系统免疫防御及其病毒对抗作用的理解。在本综述中，我们总结了cOA合成、cOA激活效应蛋白、cOA信号介导的免疫保护和cOA信号抑制方面的最新进展，并强调了cOA信号与最近发现的其他环状寡核苷酸介导的免疫之间的相互作用。
