Natural cytotoxicity impairment in familial haemophagocytic lymphohistiocytosis.
作者信息
Aricò M, Nespoli L, Maccario R, Montagna D, Bonetti F, Caselli D, Burgio G R
机构信息
Department of Paediatrics, University of Pavia, Italy.
出版信息
Arch Dis Child. 1988 Mar;63(3):292-6. doi: 10.1136/adc.63.3.292.
Abstract
Ten children with the characteristic clinical and haematological features of haemophagocytic lymphohistiocytosis are reported. Four patients treated with a combination of drugs comprising etoposide, methotrexate, and steroids were in complete remission after 10 to 30 months. Natural cytotoxic mechanisms including natural killer cell activity, antibody dependent cell mediated cytotoxicity, lymphokine activated killer cell activity, and natural killer cell like activity were persistently absent or severely impaired in these four patients despite their clinical remission. Their parents and one healthy sibling also had impaired natural cytotoxic mechanisms. Constitutional impairment of natural cytotoxic mechanisms could be important in the pathogenesis of haemophagocytic lymphohistiocytosis.
摘要
相似文献
1
Natural cytotoxicity impairment in familial haemophagocytic lymphohistiocytosis.
Arch Dis Child. 1988 Mar;63(3):292-6. doi: 10.1136/adc.63.3.292.
2
[Deteriorating natural killer activity in familial erythrophagocytic lymphohistiocytosis].[家族性噬血细胞性淋巴组织细胞增生症中自然杀伤细胞活性的恶化]
An Esp Pediatr. 1988 Aug;29(2):139-42.
3
Impaired natural killer activity in lymphohistiocytosis syndrome.
J Pediatr. 1984 Apr;104(4):569-73. doi: 10.1016/s0022-3476(84)80549-1.
4
5
Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin.使用干扰素和丙种球蛋白成功治疗非家族性噬血细胞性淋巴组织细胞增生症。
Arch Dis Child. 1996 Nov;75(5):432-5. doi: 10.1136/adc.75.5.432.
6
Defective natural killer cell function in patients with hemophagocytic lymphohistiocytosis and in first degree relatives.
Pediatr Res. 1998 Oct;44(4):465-8. doi: 10.1203/00006450-199810000-00001.
7
Immunologic dysregulation in a patient with familial hemophagocytic lymphohistiocytosis.
Cancer. 1987 Dec 1;60(11):2629-36. doi: 10.1002/1097-0142(19871201)60:11<2629::aid-cncr2820601110>3.0.co;2-q.
8
Subtyping of natural killer cell cytotoxicity deficiencies in haemophagocytic lymphohistocytosis provides therapeutic guidance.噬血细胞性淋巴组织细胞增生症中自然杀伤细胞细胞毒性缺陷的亚型分类提供了治疗指导。
Br J Haematol. 2005 Jun;129(5):658-66. doi: 10.1111/j.1365-2141.2005.05502.x.
9
Immunodeficiency in familial erythrophagocytic lymphohistiocytosis.家族性噬血细胞性淋巴组织细胞增生症中的免疫缺陷
Lancet. 1978 Mar 18;1(8064):581-3. doi: 10.1016/s0140-6736(78)91028-0.
10
Combined therapy of mice bearing a lymphokine-activated killer-resistant tumor with recombinant interleukin 2 and an antitumor monoclonal antibody capable of inducing antibody-dependent cellular cytotoxicity.用重组白细胞介素2和一种能够诱导抗体依赖性细胞毒性的抗肿瘤单克隆抗体对携带抗淋巴因子激活的杀伤细胞肿瘤的小鼠进行联合治疗。
Cancer Res. 1988 Mar 1;48(5):1173-9.
引用本文的文献
1
Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis.T 细胞检测在细胞毒性淋巴细胞胞吐作用原发性缺陷诊断中的作用。
Blood. 2024 Aug 22;144(8):873-887. doi: 10.1182/blood.2024024499.
2
Approaching hemophagocytic lymphohistiocytosis.噬血细胞性淋巴组织细胞增生症的诊治策略
Front Immunol. 2023 Jun 22;14:1210041. doi: 10.3389/fimmu.2023.1210041. eCollection 2023.
3
Matrin3 (MATR3) Expression Is Associated with Hemophagocytosis.Matrin3（MATR3）表达与噬血细胞作用相关。
Biomedicines. 2022 Sep 1;10(9):2161. doi: 10.3390/biomedicines10092161.
4
Natural Killer Cells in Systemic Autoinflammatory Diseases: A Focus on Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome.自然杀伤细胞在系统性自身炎症性疾病中的作用：以系统性幼年特发性关节炎和巨噬细胞活化综合征为例。
Front Immunol. 2020 Jan 15;10:3089. doi: 10.3389/fimmu.2019.03089. eCollection 2019.
5
Genetic dissection of NK cell responses.NK 细胞反应的遗传剖析。
Front Immunol. 2013 Jan 18;3:425. doi: 10.3389/fimmu.2012.00425. eCollection 2012.
6
Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity.家族性噬血细胞性淋巴组织细胞增生症：理解细胞细胞毒性的人类机制的模型。
Cell Mol Life Sci. 2012 Jan;69(1):29-40. doi: 10.1007/s00018-011-0835-y. Epub 2011 Oct 12.
7
Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis.儿童活性噬血细胞性淋巴组织细胞增生症外周血单个核细胞的基因表达谱分析。
Blood. 2011 Apr 14;117(15):e151-60. doi: 10.1182/blood-2010-08-300046. Epub 2011 Feb 16.
8
Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3.家族性噬血细胞性淋巴组织细胞增生症 3 型的基因型-表型研究。
J Med Genet. 2011 May;48(5):343-52. doi: 10.1136/jmg.2010.085456. Epub 2011 Jan 19.
9
STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5.STXBP2 突变与家族性噬血细胞性淋巴组织细胞增多症 5 型。
J Med Genet. 2010 Sep;47(9):595-600. doi: 10.1136/jmg.2009.075341.
10
Familial hemophagocytic lymphohistiocytosis: clinical and neuroradiological findings and review of the literature.家族性噬血细胞性淋巴组织细胞增生症：临床与神经放射学表现及文献综述
Childs Nerv Syst. 2010 Jan;26(1):121-7. doi: 10.1007/s00381-009-0957-9. Epub 2009 Aug 1.
本文引用的文献
1
Familial haemophagocytic reticulosis.家族性噬血细胞性网状细胞增生症
Arch Dis Child. 1952 Dec;27(136):519-25. doi: 10.1136/adc.27.136.519.
2
Successful treatment of lymphohistiocytic reticulosis with phagocytosis with epipodophyllotoxin VP 16-213.
Cancer. 1980 May 15;45(10):2516-20. doi: 10.1002/1097-0142(19800515)45:10<2516::aid-cncr2820451008>3.0.co;2-v.
3
4
[Immunologic study of familial lymphohistiocytosis. Eight new case reports (author's transl)].家族性淋巴细胞组织细胞增生症的免疫学研究。八例新病例报告（作者译）
Arch Fr Pediatr. 1982 Mar;39(3):135-40.
5
[Disequilibrium of lymphocytic sub-groups in an child with familial lymphohistiocytosis].[一名患有家族性淋巴细胞组织细胞增多症儿童的淋巴细胞亚群失衡]
Arch Fr Pediatr. 1983 Feb;40(2):129-30.
6
Genetic analysis of familial erythrophagocytic lymphohistiocytosis.
Eur J Pediatr. 1984 Sep;142(4):248-52. doi: 10.1007/BF00540245.
7
Heterogeneity of natural killer cells.自然杀伤细胞的异质性。
Annu Rev Immunol. 1984;2:359-94. doi: 10.1146/annurev.iy.02.040184.002043.
8
Impaired natural killer activity in lymphohistiocytosis syndrome.
J Pediatr. 1984 Apr;104(4):569-73. doi: 10.1016/s0022-3476(84)80549-1.
9
Familial hemophagocytic lymphohistiocytosis.家族性噬血细胞性淋巴组织细胞增生症
Eur J Pediatr. 1983 Jun-Jul;140(3):221-30. doi: 10.1007/BF00443367.
10
Natural killer cell function of human neonatal lymphocytes.人类新生儿淋巴细胞的自然杀伤细胞功能。
Clin Exp Immunol. 1982 Jun;48(3):649-54.
Zotero 插件