Abdel-Mobdy Ahmed E, Khattab Marwa S, Mahmoud Ebtesam A, Mohamed Eman R, Abdel-Rahim Emam A
Faculty of Agriculture, Dairy Sciences Department, Cairo University, Giza, Egypt.
Faculty of Veterinary Medicine, Pathology Department, Cairo University, Giza, Egypt.
Food Sci Biotechnol. 2020 Nov 4;30(1):107-116. doi: 10.1007/s10068-020-00842-3. eCollection 2021 Jan.
Lifestyle and diet preferences are primarily responsible for developing type 2 diabetes. In this study, okara was manufactured into okara whey crackers (OWC) to investigate its dietary role in controlling diabetes in streptozotocin-diabetic rats with and without a high-fat diet. Forty-eight rats were divided into eight groups. G1-G4 were nondiabetic and fed a basal diet, a basal diet with 30% crackers, high fat diet, and a high-fat diet with 30% crackers, respectively. G5-G8 were diabetic groups that received similar diets as previous groups. Blood glucose, liver function, lipid pattern, pancreas and liver histopathology, and insulin immunohistochemistry were performed. OWC improved measured parameters and histopathology of the liver and pancreas in diabetic rats. The area % of positive insulin cells was increased in G6 (5.20%) and G8 rats (2.83%) fed OWC compared to diabetic rats (1.17%). In conclusion, the use of 30% OWC in a semi-modified diet has controlled the hyperglycemia and hyperlipidemia associated with diabetes.
生活方式和饮食偏好是导致2型糖尿病的主要原因。在本研究中，豆渣被制成豆渣乳清饼干（OWC），以研究其在有或无高脂饮食的链脲佐菌素诱导的糖尿病大鼠中对控制糖尿病的饮食作用。48只大鼠被分为八组。G1 - G4为非糖尿病组，分别喂食基础饮食、含30%饼干的基础饮食、高脂饮食和含30%饼干的高脂饮食。G5 - G8为糖尿病组，接受与先前组相似的饮食。进行了血糖、肝功能、血脂模式、胰腺和肝脏组织病理学以及胰岛素免疫组织化学检测。OWC改善了糖尿病大鼠的测量参数以及肝脏和胰腺的组织病理学。与糖尿病大鼠（1.17%）相比，喂食OWC的G6组（5.20%）和G8组大鼠（2.83%）中胰岛素阳性细胞的面积百分比增加。总之，在半改良饮食中使用30%的OWC可控制与糖尿病相关的高血糖和高血脂。
