Elfasi Aisha, Echevarria Franklin D, Rodriguez Robert, Roman Casul Yoram A, Khanna Anna Yuzefovich, Mankowski Robert T, Simpkins Alexis N
University of Florida, Department of Neurology, Gainesville, FL, USA.
University of Florida, Department of Aging and Geriatric Research, Gainesville, FL, USA.
eNeurologicalSci. 2021 Mar;22:100325. doi: 10.1016/j.ensci.2021.100325. Epub 2021 Feb 1.
With the ever-expanding population of patients infected with SARS-CoV-2, we are learning more about the immediate and long-term clinical manifestations of coronavirus disease 2019 (COVID-19). Ischemic stroke (IS) is now one of the well-documented additional clinical manifestations of COVID-19. Most COVID-19 related IS cases have been categorized as cryptogenic or embolic stroke of undetermined source (ESUS), which are most often suspected to have an undiagnosed cardioembolic source. COVID-19 is known to also cause cardiac dysfunction, heart failure, and atrial arrhythmias (AA), but the long-term impact of this cardiac dysfunction on stroke incidence is unknown. With millions afflicted with COVID-19 and the ever-rising infection rate, it is important to consider the potential long-term impact of COVID-19 on future IS incidence. Accomplishing these goals will require novel strategies that allow for diagnosis, data capture, and prediction of future IS risk using tools that are adaptable to the evolving clinical challenges in patient care delivery and research.
随着感染严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的患者数量不断增加，我们对2019冠状病毒病（COVID-19）的即时和长期临床表现有了更多了解。缺血性卒中（IS）现已成为COVID-19另一种有充分文献记载的临床表现。大多数与COVID-19相关的IS病例被归类为隐源性卒中或不明来源栓塞性卒中（ESUS），这些病例最常被怀疑有未被诊断出的心脏栓子来源。已知COVID-19还会导致心脏功能障碍、心力衰竭和房性心律失常（AA），但这种心脏功能障碍对卒中发病率的长期影响尚不清楚。由于数百万患者感染了COVID-19且感染率不断上升，考虑COVID-19对未来IS发病率的潜在长期影响非常重要。要实现这些目标，将需要采用新的策略，利用适用于患者护理和研究中不断演变的临床挑战的工具，来进行未来IS风险的诊断、数据收集和预测。
