Krupp L B, Alvarez L A, LaRocca N G, Scheinberg L C
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.
Arch Neurol. 1988 Apr;45(4):435-7. doi: 10.1001/archneur.1988.00520280085020.
Fatigue is a frequent symptom in multiple sclerosis (MS) that can interfere with a patient's daily functioning. The cause of MS fatigue, its clinical characteristics, and its relationship to other symptoms remain poorly understood. Structured interviews were conducted with 32 patients with MS and 33 normal healthy adults. Fatigue proved to be both more frequent and more severe among the patients with MS. Multiple sclerosis fatigue was unrelated to either depression or global impairment. Multiple sclerosis fatigue appears to be a distinct clinical entity, often disabling, that can be distinguished from normal fatigue, affective disturbance, and neurologic impairment.
疲劳是多发性硬化症（MS）中常见的症状，会干扰患者的日常功能。MS疲劳的病因、临床特征及其与其他症状的关系仍知之甚少。对32例MS患者和33名正常健康成年人进行了结构化访谈。结果证明，MS患者中的疲劳更为常见且更为严重。MS疲劳与抑郁或整体功能损害均无关。MS疲劳似乎是一种独特的临床实体，常常导致残疾，可与正常疲劳、情感障碍和神经功能损害相区分。
