Department of Kinesiology and Community Health, University of Illinois, Urbana, IL, USA.
J Neurosci Nurs. 2010 Aug;42(4):212-6. doi: 10.1097/jnn.0b013e3181e26c5f.
This study examined the symptom cluster of fatigue, pain, and depression as a correlate of reduced quality of life (QOL) in individuals with multiple sclerosis (MS). The sample included 291 individuals with a definite diagnosis of MS who were enrolled in a 6-month longitudinal study of physical activity and QOL. The participants completed baseline measures of fatigue, depression, and pain and follow-up measures of QOL. Cluster analysis initially identified three subgroups differing in experiences of fatigue, depression, and pain, and analysis of variance then indicated that the three subgroups differed in QOL. The subgroup with lowest scores on all three symptoms had the highest QOL, whereas the subgroup with the highest scores on the symptoms had the worst QOL. Such findings provide preliminary support for fatigue, pain, and depression as a symptom cluster that correlates with reduced QOL in persons with MS.
本研究考察了多发性硬化症（MS）患者疲劳、疼痛和抑郁症状群与生活质量（QOL）降低的相关性。该样本包括 291 名确诊为 MS 的患者，他们参加了一项为期 6 个月的身体活动和 QOL 纵向研究。参与者完成了疲劳、抑郁和疼痛的基线测量以及 QOL 的随访测量。聚类分析最初确定了在疲劳、抑郁和疼痛体验方面存在差异的三个亚组，方差分析表明这三个亚组在 QOL 方面存在差异。在所有三个症状上得分最低的亚组的 QOL 最高，而在症状上得分最高的亚组的 QOL 最差。这些发现初步支持疲劳、疼痛和抑郁是一个症状群，与 MS 患者的 QOL 降低相关。
