Liao Jiaqiang, Fan Shibing, Chen Jing, Wu Jianglin, Xu Shunqing, Guo Yuming, Li Chunhui, Zhang Xianxiang, Wu Chuansha, Mou Huaming, Song Chenxi, Li Feng, Wu Guicheng, Zhang Jingjing, Guo Lian, Liu Huawen, Lv Jinglong, Xu Lixin, Lang Chunhui
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
Department of Neurosurgery, Chongqing University Three Gorges Hospital & Chongqing Three Gorges Central Hospital, NO.165 Xincheng Road, Wanzhou, Chongqing 404000, People's Republic of China.
Innovation (Camb). 2020 May 21;1(1):100001. doi: 10.1016/j.xinn.2020.04.001. Epub 2020 May 20.
Adolescents and young adults might play a key role in the worldwide spread of Coronavirus Disease 2019 (COVID-19) because they are more likely to be involved in overseas study, business, work, and travel. However, the epidemiological and clinical characteristics remain unknown.
We collected demographic, epidemiological, and clinical data from 46 confirmed COVID-19 patients aged 10 to 35 years from the Chongqing Three Gorges Central Hospital. Several key epidemiological parameters, asymptomatic cases, transmission to family members, and clinical characteristics at admission and during treatment were summarized.
Of 46 confirmed patients, 14 patients (30.4%) were aged between 10 and 24 years, and 24 (52.2%) patients were male. The estimated mean incubation period was 6.6 days (95% confidence interval [CI] 4.4-9.6). The median serial interval was 1.9 days (95% CI 0.4-6.2). Three of the asymptomatic cases showed transmission to their family members. Only one patient was identified as a severe case at admission. The common symptoms at admission were dry cough (34, 81.0%) and fever (29, 69.1%). Nearly 60% of the patients showed ground-glass opacity on chest computed tomography. Three patients developed acute kidney injury during treatment. Most of the patients (78.3%) recovered and were discharged by the end of the follow-up.
This single-center study with a relatively small sample size showed that adolescent and young adult patients with COVID-19 had a long incubation period and a short serial interval. The transmission occurred from asymptomatic cases to family members. Fewer patients developed complications during treatment.
青少年和青年在2019冠状病毒病（COVID-19）的全球传播中可能起关键作用，因为他们更有可能参与海外学习、商务、工作和旅行。然而，其流行病学和临床特征仍不清楚。
我们收集了重庆三峡中心医院46例年龄在10至35岁之间的确诊COVID-19患者的人口统计学、流行病学和临床数据。总结了几个关键的流行病学参数、无症状病例、向家庭成员的传播情况以及入院时和治疗期间的临床特征。
46例确诊患者中，14例（30.4%）年龄在10至24岁之间，24例（52.2%）为男性。估计平均潜伏期为6.6天（95%置信区间[CI]4.4 - 9.6）。中位连续间隔时间为1.9天（95%CI 0.4 - 6.2）。3例无症状病例出现了向其家庭成员的传播。入院时仅1例患者被确定为重症病例。入院时常见症状为干咳（34例，81.0%）和发热（29例，69.1%）。近60%的患者胸部计算机断层扫描显示磨玻璃影。3例患者在治疗期间发生急性肾损伤。大多数患者（78.3%）在随访结束时康复出院。
这项样本量相对较小的单中心研究表明，COVID-19青少年和青年患者潜伏期长、连续间隔时间短。传播发生在无症状病例向家庭成员之间。治疗期间发生并发症的患者较少。
