热量限制作为炎症性疾病的新治疗方法。
Calorie Restriction as a New Treatment of Inflammatory Diseases.
机构信息
Université de Lorraine, Inserm U1256 NGERE (Nutrition-Genetics and Exposure to Environmental Risks), Nancy, France.
Université de Lorraine, Centre Hospitalier Régional Universitaire (CHRU)-Nancy, Department of Diabetology-Endocrinology-Nutrition, Nancy, France.
出版信息
Adv Nutr. 2021 Jul 30;12(4):1558-1570. doi: 10.1093/advances/nmaa179.
Abstract
Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society. The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy intake and adiposity cause systemic inflammation, whereas calorie restriction (CR) without malnutrition, exerts a potent anti-inflammatory effect. The objective of this review was to provide an overview of different strategies used to reduce calorie intake, discuss physiological mechanisms by which CR might lead to improved health outcomes, and summarize the present knowledge about inflammatory diseases. We discuss emerging data of observational studies and randomized clinical trials on CR that have been shown to reduce inflammation and improve human health.
摘要
过度的卡路里摄入加上久坐不动的生活方式是现代社会健康问题和炎症性疾病的主要决定因素。能量消耗和能量支出之间的平衡对长寿至关重要。过多的能量摄入和肥胖会导致全身炎症，而在不过度营养不良的情况下限制卡路里摄入则会产生强烈的抗炎作用。本综述的目的是提供不同减少卡路里摄入策略的概述，讨论 CR 可能导致改善健康结果的生理机制，并总结有关炎症性疾病的现有知识。我们讨论了关于 CR 的观察性研究和随机临床试验的新数据，这些研究表明 CR 可以减轻炎症并改善人类健康。
相似文献
1
Calorie Restriction as a New Treatment of Inflammatory Diseases.热量限制作为炎症性疾病的新治疗方法。
Adv Nutr. 2021 Jul 30;12(4):1558-1570. doi: 10.1093/advances/nmaa179.
2
Health Benefits of Fasting and Caloric Restriction.禁食和热量限制对健康的益处。
Curr Diab Rep. 2017 Oct 23;17(12):123. doi: 10.1007/s11892-017-0951-7.
3
Caloric restriction for the immunometabolic control of human health.热量限制对人类健康免疫代谢的控制作用。
Cardiovasc Res. 2024 Feb 17;119(18):2787-2800. doi: 10.1093/cvr/cvad035.
4
Feeding the critically ill obese patient: a systematic review protocol.为危重症肥胖患者提供营养支持：一项系统评价方案
JBI Database System Rev Implement Rep. 2015 Oct;13(10):95-109. doi: 10.11124/jbisrir-2015-2458.
5
Aging, adiposity, and calorie restriction.衰老、肥胖与热量限制。
JAMA. 2007 Mar 7;297(9):986-94. doi: 10.1001/jama.297.9.986.
6
Calorie restriction and cardiometabolic health.热量限制与心脏代谢健康。
Eur J Cardiovasc Prev Rehabil. 2008 Feb;15(1):3-9. doi: 10.1097/HJR.0b013e3282f17bd4.
7
Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction.炎症调节中的神经内分泌因素：过度肥胖与热量限制
Exp Gerontol. 2009 Jan-Feb;44(1-2):41-5. doi: 10.1016/j.exger.2008.04.005. Epub 2008 Apr 12.
8
Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.能量摄入减少长期效应综合评估（CALERIE）-2研究中的身体成分变化：一项针对非肥胖人群进行的为期2年的热量限制随机对照试验。
Am J Clin Nutr. 2017 Apr;105(4):913-927. doi: 10.3945/ajcn.116.137232. Epub 2017 Feb 22.
9
Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging.饮食中蛋氨酸限制对全身炎症的转录影响：与衰老过程中代谢疾病生物标志物的相关性。
Biofactors. 2014 Jan-Feb;40(1):13-26. doi: 10.1002/biof.1111. Epub 2013 Jun 29.
10
Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.6个月热量限制对超重个体长寿、代谢适应及氧化应激生物标志物的影响：一项随机对照试验
JAMA. 2006 Apr 5;295(13):1539-48. doi: 10.1001/jama.295.13.1539.
引用本文的文献
1
Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress.术后食欲减退中的情感-认知回路：对外科手术应激的适应性神经免疫反应。
Front Neurosci. 2025 Aug 12;19:1654559. doi: 10.3389/fnins.2025.1654559. eCollection 2025.
2
Understanding and improving vaccine efficacy in older adults.了解并提高老年人的疫苗效力。
Nat Aging. 2025 Aug;5(8):1455-1470. doi: 10.1038/s43587-025-00939-6. Epub 2025 Aug 14.
3
Genome-wide association and functional annotation analyses reveal candidate genes and pathways associated with various ewe longevity indicators in U.S. Katahdin sheep.全基因组关联和功能注释分析揭示了与美国卡他丁绵羊各种母羊长寿指标相关的候选基因和途径。
Front Genet. 2025 Jul 3;16:1600587. doi: 10.3389/fgene.2025.1600587. eCollection 2025.
4
Quantitative Multi-Parameter MRI Evaluation of Hashimoto's Thyroiditis Changes After Dietary Interventions.饮食干预后桥本甲状腺炎变化的定量多参数磁共振成像评估
Med Sci Monit. 2025 Jul 10;31:e947862. doi: 10.12659/MSM.947862.
5
The impact of dietary restriction on transcriptional profiles of hematopoietic stem cells in aged female mice.饮食限制对老年雌性小鼠造血干细胞转录谱的影响。
Biogerontology. 2025 Jun 20;26(4):122. doi: 10.1007/s10522-025-10263-6.
6
Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease.自我吞噬的肠道：自噬在胃肠道健康与疾病中的作用
Gastro Hep Adv. 2025 Mar 15;4(6):100654. doi: 10.1016/j.gastha.2025.100654. eCollection 2025.
7
Caloric restriction mimetic 2-deoxyglucose alters metabolic and transcriptomic phenotype in association with changes in chromatin accessibility in human astrocytes.热量限制模拟物2-脱氧葡萄糖改变人类星形胶质细胞的代谢和转录组表型，并与染色质可及性变化相关。
Sci Rep. 2025 Jun 3;15(1):19368. doi: 10.1038/s41598-025-03796-w.
8
Caloric Restriction and Sirtuins as New Players to Reshape Male Fertility.热量限制与沉默调节蛋白：重塑男性生育能力的新因素
Metabolites. 2025 May 2;15(5):303. doi: 10.3390/metabo15050303.
9
Phenotyping the Chemical Communications of the Intestinal Microbiota and the Host: Secondary Bile Acids as Postbiotics.肠道微生物群与宿主化学通讯的表型分析：次级胆汁酸作为益生元后体。
Cells. 2025 Apr 15;14(8):595. doi: 10.3390/cells14080595.
10
Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response.针对银屑病中的细胞因子失调：饮食干预在调节免疫反应中的作用。
Int J Mol Sci. 2025 Mar 22;26(7):2895. doi: 10.3390/ijms26072895.
本文引用的文献
1
Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.隔日禁食、限时进食和间歇性能量限制对 DSS 诱导的结肠炎和行为障碍的影响。
Redox Biol. 2020 May;32:101535. doi: 10.1016/j.redox.2020.101535. Epub 2020 Apr 10.
2
Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States.酮体对细胞生物化学、表观遗传学和代谢组学的调节。生酮饮食在生物体生理和病理状态中的意义。
Nutrients. 2020 Mar 17;12(3):788. doi: 10.3390/nu12030788.
3
Intermittent Fasting as Part of the Management for T2DM: from Animal Models to Human Clinical Studies.间歇性禁食作为2型糖尿病管理的一部分：从动物模型到人体临床研究
Curr Diab Rep. 2020 Mar 12;20(4):13. doi: 10.1007/s11892-020-1295-2.
4
Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment.热量限制延长寿命：新型饮食策略在当前致肥胖环境中的作用。
Ageing Res Rev. 2020 Dec;64:101038. doi: 10.1016/j.arr.2020.101038. Epub 2020 Feb 25.
5
The Effects of Low-Energy Moderate-Carbohydrate (MCD) and Mixed (MixD) Diets on Serum Lipid Profiles and Body Composition in Middle-Aged Men: A Randomized Controlled Parallel-Group Clinical Trial.中等能量低碳水化合物（MCD）饮食和混合（MixD）饮食对中年男性血脂谱和身体成分的影响：一项随机对照平行组临床试验。
Int J Environ Res Public Health. 2020 Feb 19;17(4):1332. doi: 10.3390/ijerph17041332.
6
A Delayed Morning and Earlier Evening Time-Restricted Feeding Protocol for Improving Glycemic Control and Dietary Adherence in Men with Overweight/Obesity: A Randomized Controlled Trial.限时进食方案对超重/肥胖男性血糖控制和饮食依从性的影响：一项随机对照试验。
Nutrients. 2020 Feb 17;12(2):505. doi: 10.3390/nu12020505.
7
Cardiovascular benefits of intermittent fasting.间歇性禁食对心血管的益处。
Cardiovasc Res. 2020 Mar 1;116(3):e36-e38. doi: 10.1093/cvr/cvaa022.
8
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.肠道微生物群介导间歇性禁食缓解糖尿病引起的认知障碍。
Nat Commun. 2020 Feb 18;11(1):855. doi: 10.1038/s41467-020-14676-4.
9
Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases.脂联素在炎症和疾病中的多方面生理作用。
Int J Mol Sci. 2020 Feb 12;21(4):1219. doi: 10.3390/ijms21041219.
10
Dietary Restriction and Epigenetics: Part I.饮食限制与表观遗传学：第一部分。
Cond Med. 2019 Dec;2(6):284-299.
Zotero 插件