Thomas A D, Forbes-Faulkner J C, Norton J H, Trueman K F
Oonoonba Veterinary Laboratory, Townsville, Queensland.
Aust Vet J. 1988 Feb;65(2):43-6. doi: 10.1111/j.1751-0813.1988.tb07350.x.
The effects in goats of the subcutaneous injection of varying doses of Pseudomonas pseudomallei (90 to 500,000 bacilli) suspended in normal saline are described. High doses (greater than or equal to 500 bacilli) caused acute, fatal infections. Lower doses (90 to 225 bacilli) caused acute or chronic disease when infection became established. However, 11 of 18 goats injected with the lower doses of bacilli showed no sign of infection on clinical or bacteriological examination. Response to antibiotic therapy with long acting tetracycline and chloramphenicol was minimal. Goats surviving the initial phase of infection tended to overcome the disease with a corresponding increase in the number of abscesses that were sterile at necropsy. In infected goats, clinical signs included undulating fever, wasting, anorexia, paresis of the hind legs, severe mastitis and abortion. At necropsy, abscesses were found predominantly in the spleen, lungs, subcutaneous injection site and its draining lymph node.
本文描述了山羊皮下注射不同剂量（90至500,000个杆菌）悬浮于生理盐水中的类鼻疽杆菌后的效应。高剂量（大于或等于500个杆菌）会引发急性致命感染。较低剂量（90至225个杆菌）在感染确立时会导致急性或慢性疾病。然而，18只注射较低剂量杆菌的山羊中有11只在临床或细菌学检查中未显示感染迹象。长效四环素和氯霉素的抗生素治疗效果甚微。在感染初始阶段存活下来的山羊往往能战胜疾病，尸检时无菌脓肿数量相应增加。感染山羊的临床症状包括波状热、消瘦、厌食、后腿轻瘫、严重乳腺炎和流产。尸检时，脓肿主要见于脾脏、肺、皮下注射部位及其引流淋巴结。
