Siddiqui Ruqaiyyah, Mungroo Mohammad Ridwane, Khan Naveed Ahmed
College of Arts and Sciences, American University of Sharjah, University City, Sharjah, United Arab Emirates.
Department of Clinical Sciences, College of Medicine, University of Sharjah, University City, Sharjah, United Arab Emirates.
Hosp Pract (1995). 2021 Aug;49(3):157-163. doi: 10.1080/21548331.2021.1887677. Epub 2021 Mar 1.
There is increasing evidence of the ability of the novel coronavirus to invade the central nervous system (CNS). But how does a respiratory virus invade the highly protected CNS? Here, we reviewed available literature and case reports to determine CNS involvement in COVID-19, and to identify potential regions of the brain that may be affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible route of entry into the brain to identify its pathogenicity. Based on the symptoms, the parietal lobe and the cerebellum are the likely targets of SARS-CoV-2; however, further work is needed to elucidate this. The presence of ACE2, used by SARS-CoV-2 for cell entry, in the brain as well as detection of the virus in the cerebrospinal fluid, further assert that SARS-COV-2 targets the brain, and therefore, medical practitioners should take that into account when dealing with patients suffering from COVID-19.
越来越多的证据表明新型冠状病毒能够侵入中枢神经系统（CNS）。但是一种呼吸道病毒是如何侵入受到高度保护的中枢神经系统的呢？在这里，我们回顾了现有文献和病例报告，以确定中枢神经系统在冠状病毒病（COVID-19）中的受累情况，并识别可能受到严重急性呼吸综合征冠状病毒2（SARS-CoV-2）影响的潜在脑区及其进入大脑的可能途径，以确定其致病性。根据症状，顶叶和小脑可能是SARS-CoV-2的靶标；然而，需要进一步的研究来阐明这一点。SARS-CoV-2用于进入细胞的血管紧张素转换酶2（ACE2）在大脑中的存在以及在脑脊液中检测到该病毒，进一步证实SARS-CoV-2靶向大脑，因此，医务人员在治疗COVID-19患者时应考虑到这一点。
