Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
BMC Pediatr. 2023 Jan 30;23(1):49. doi: 10.1186/s12887-022-03806-0.
There is growing evidence of nervous system involvement and related complaints in children with coronavirus disease 2019 (COVID-19). However, it seems that attempts to track of the virus in the nervous system have so far been unsuccessful.
Here we describe two pediatric cases of severe COVID-19 who had positive cerebrospinal fluid (CSF) and nasopharyngeal polymerase chain reaction (PCR) tests for severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2). A 36-month-old girl who presented with fever, diarrhea, mild left ventricular dysfunction and bizarre movements, and a five-month-old boy who presented with fever, watery diarrhea, severe dehydration, mottling, and two episodes of seizure. Their CSF analyses and cultures were normal. They admitted in intensive care unit (ICU) for near four days and discharged after ten days without any complaint.
This is one of the first reports of the presence of coronavirus in the central nervous system in COVID-19 pediatric patients, emphasizing the neurotropism and neuroinvasion characteristics of the virus.
越来越多的证据表明，2019 冠状病毒病（COVID-19）患儿存在神经系统受累及相关主诉。然而，目前似乎还未能成功追踪到病毒在神经系统中的存在。
在此我们描述了两例重症 COVID-19 儿科病例，其重症急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）的脑脊液（CSF）和鼻咽聚合酶链反应（PCR）检测均为阳性。一名 36 月龄女孩表现为发热、腹泻、轻度左心室功能障碍和奇异运动，另一名 5 月龄男孩表现为发热、水样腹泻、严重脱水、斑片状和两次癫痫发作。他们的 CSF 分析和培养均正常。他们在重症监护病房（ICU）中接受了近四天的治疗，十天后没有任何不适出院。
这是 COVID-19 儿科患者中枢神经系统中存在冠状病毒的首批报告之一，强调了病毒的嗜神经性和神经侵袭性特征。
