Lu Qingchun, Wang Po-Shun, Yang Ling
Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, 3440 N Broad St, Kresge Hall, Rm. 624, Philadelphia, PA19140, USA.
Cell Biosci. 2021 Feb 8;11(1):35. doi: 10.1186/s13578-021-00543-2.
Autophagy is a conserved cellular degradation process in eukaryotes that facilitates the recycling and reutilization of damaged organelles and compartments. It plays a pivotal role in cellular homeostasis, pathophysiological processes, and diverse diseases in humans. Autophagy involves dynamic crosstalk between different stages associated with intracellular vesicle trafficking. Golgi apparatus is the central organelle involved in intracellular vesicle trafficking where Golgi-associated Rab GTPases function as important mediators. This review focuses on the recent findings that highlight Golgi-associated Rab GTPases as master regulators of autophagic flux. The scope for future research in elucidating the role and mechanism of Golgi-associated Rab GTPases in autophagy and autophagy-related diseases is discussed further.
自噬是真核生物中一种保守的细胞降解过程，它有助于受损细胞器和区室的回收和再利用。它在细胞内稳态、病理生理过程以及人类的多种疾病中起着关键作用。自噬涉及与细胞内囊泡运输相关的不同阶段之间的动态相互作用。高尔基体是参与细胞内囊泡运输的中心细胞器，其中与高尔基体相关的Rab GTPases作为重要的介质发挥作用。本综述重点关注了最近的研究发现，这些发现突出了与高尔基体相关的Rab GTPases作为自噬通量的主要调节因子。进一步讨论了未来研究在阐明与高尔基体相关的Rab GTPases在自噬及自噬相关疾病中的作用和机制方面的前景。
