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ergothioneine,最新进展。

Ergothioneine, recent developments.

机构信息

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore; Life Science Institute, Neurobiology Programme, Centre for Life Sciences, National University of Singapore, 117456, Singapore.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore; Life Science Institute, Neurobiology Programme, Centre for Life Sciences, National University of Singapore, 117456, Singapore.

出版信息

Redox Biol. 2021 Jun;42:101868. doi: 10.1016/j.redox.2021.101868. Epub 2021 Jan 26.

DOI:10.1016/j.redox.2021.101868
PMID:33558182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8113028/
Abstract

There has been a recent surge of interest in the unique low molecular weight dietary thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from diet and may play important physiological roles in human health and development, and possibly in prevention and treatment of disease. Blood levels of ergothioneine decline with age and onset of various diseases. Here we highlight recent advances in our knowledge of ergothioneine.

摘要

最近,人们对独特的低分子量膳食硫醇/硫酮——麦硫因产生了浓厚的兴趣。这种化合物可以通过饮食在体内大量积累,可能在人类健康和发育中发挥重要的生理作用,并且可能在疾病的预防和治疗中发挥作用。麦硫因的血液水平会随着年龄的增长和各种疾病的发作而下降。在这里,我们重点介绍了麦硫因知识的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b4/8113028/f21fc44542ab/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b4/8113028/28dc7760a1a8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b4/8113028/f21fc44542ab/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b4/8113028/28dc7760a1a8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b4/8113028/f21fc44542ab/gr2.jpg

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Ergothioneine, recent developments.ergothioneine,最新进展。
Redox Biol. 2021 Jun;42:101868. doi: 10.1016/j.redox.2021.101868. Epub 2021 Jan 26.
2
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Ergothioneine; antioxidant potential, physiological function and role in disease.麦角硫因;抗氧化潜力、生理功能及在疾病中的作用。
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Mushrooms: A rich source of the antioxidants ergothioneine and glutathione.蘑菇:抗氧化剂麦角硫因和谷胱甘肽的丰富来源。
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Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease.肉碱/有机阳离子转运体 1-麦硫因轴的损伤是由慢性肾脏病中的肠道转运体功能障碍介导的。
Kidney Int. 2017 Dec;92(6):1356-1369. doi: 10.1016/j.kint.2017.04.032. Epub 2017 Jul 26.

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本文引用的文献

1
Is ergothioneine a 'longevity vitamin' limited in the American diet?ergothioneine 是一种“长寿维生素”吗?它在美国饮食中有限制吗?
J Nutr Sci. 2020 Nov 11;9:e52. doi: 10.1017/jns.2020.44. eCollection 2020.
2
Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.通过功能基因组学研究揭示溶质载体 22 家族成员 SLC22A15 的功能。
FASEB J. 2020 Dec;34(12):15734-15752. doi: 10.1096/fj.202001497R. Epub 2020 Oct 30.
3
Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury.麦硫因对 7-酮胆固醇诱导的内皮损伤的影响。
麦角硫因治疗改善帕金森病模型的病理表型。
J Neurochem. 2025 Jul;169(7):e70168. doi: 10.1111/jnc.70168.
4
Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review).微生物群代谢产物作为脑-肠通讯的驱动因素影响睡眠(综述)。
Int J Mol Med. 2025 Sep;56(3). doi: 10.3892/ijmm.2025.5571. Epub 2025 Jul 4.
5
Study protocol: The efficacy of mushroom to prevent cognitive decline in at-risk middle-aged adults and young-olds living in the community.研究方案:蘑菇对预防社区中处于认知衰退风险的中年人和老年人认知能力下降的功效。
Front Aging Neurosci. 2025 Jun 9;17:1588493. doi: 10.3389/fnagi.2025.1588493. eCollection 2025.
6
Ultrasound-Triggered Nanocomposite "Lever" Hydrogels with a Full Repair System Accelerates Diabetic Foot Ulcer Repair.具有完整修复系统的超声触发纳米复合“杠杆”水凝胶可加速糖尿病足溃疡修复。
Adv Sci (Weinh). 2025 Jun;12(23):e2500720. doi: 10.1002/advs.202500720. Epub 2025 May 8.
7
AG86 Peptide-modified Reactive Oxygen Species-responsive Polymer Nanovesicles for Transdermal Delivery of Hydrophilic Ergothioneine to Basal Keratinocytes.用于将亲水性麦角硫因经皮递送至基底角质形成细胞的AG86肽修饰的活性氧响应性聚合物纳米囊泡。
AAPS PharmSciTech. 2025 May 9;26(5):128. doi: 10.1208/s12249-025-03122-7.
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The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review.麦角硫因在认知及年龄相关性神经退行性疾病中的作用:一项系统综述。
Inflammopharmacology. 2025 Apr 18. doi: 10.1007/s10787-025-01746-6.
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Effects of ergothioneine on oxidative DNA damage and immune response induced by circadian rhythm disturbance in mice.麦角硫因对昼夜节律紊乱诱导的小鼠氧化DNA损伤和免疫反应的影响。
J Clin Biochem Nutr. 2025 Mar;76(2):117-124. doi: 10.3164/jcbn.24-220. Epub 2024 Dec 26.
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Antioxidants (Basel). 2020 Sep 13;9(9):855. doi: 10.3390/antiox9090855.
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Neurochem Res. 2020 Nov;45(11):2664-2678. doi: 10.1007/s11064-020-03118-8. Epub 2020 Aug 26.
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