Takhor Nurfarah Hazwani, Phan Chia Wei
Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Neuroscience Research Group (NeuRG), Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Inflammopharmacology. 2025 Apr 18. doi: 10.1007/s10787-025-01746-6.
Ergothioneine (ET) is an under recognised diet-derived compound which has the potential to be a "longevity vitamin". It was found to be beneficial for cognitive function and age-related neurodegenerative disorder (ARND). Thus, this study was conducted to synthesise the existing evidence of ET's effects on cognition and ARND, emphasizing its potential as a micronutrient for healthy aging. This study also highlights the future prospects of the research regarding ET's effects on cognition and ARND that are suggested in existing literature. Three databases (Pubmed, Scopus, and Web of Science) were used to search for the studies that meet the inclusion and exclusion criteria. A total of 19 studies were included after screening in this review. The risk of bias of each study was assessed using the Office of Health Assessment and Translation (OHAT) risk of bias rating tool. All studies' characteristics and main findings were tabulated according to their type of study. Mechanisms of ET in improving cognitive function and preventing ARND were found to be through its antioxidative, anti-inflammatory and antisenescence properties. Its role in neurotransmission and neuroprotection also contributed to improving cognition and preventing ARND. In conclusion, ET is a potential compound to be explored as its role in cognition and ARND have been discovered through several studies.
麦角硫因（ET）是一种未得到充分认识的饮食衍生化合物，有潜力成为一种“长寿维生素”。它被发现对认知功能和年龄相关神经退行性疾病（ARND）有益。因此，本研究旨在综合ET对认知和ARND影响的现有证据，强调其作为健康衰老的微量营养素的潜力。本研究还突出了现有文献中关于ET对认知和ARND影响的研究的未来前景。使用三个数据库（PubMed、Scopus和Web of Science）搜索符合纳入和排除标准的研究。经过筛选，本综述共纳入19项研究。使用健康评估与转化办公室（OHAT）偏倚风险评级工具评估每项研究的偏倚风险。根据研究类型将所有研究的特征和主要发现制成表格。发现ET改善认知功能和预防ARND的机制是通过其抗氧化、抗炎和抗衰老特性。其在神经传递和神经保护中的作用也有助于改善认知和预防ARND。总之，由于多项研究已发现ET在认知和ARND中的作用，它是一种有待探索的潜在化合物。
